Clinical Study of FRC Implant to Treat Skull Bone Defects

NCT ID: NCT01874613

Last Updated: 2015-02-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

19 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2019-12-31

Brief Summary

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Bioactive fibre-reinforced composite implant is used for reconstruction of skull bone defects and orbital floor defects.

Functional and aesthetic outcome is assessed by patient and doctor.

Detailed Description

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Development phase: Clinical trial Objectives: Assessment of functional and aesthetic outcome Methodology: Intervention study Sample size: 35+20+25 Main criteria for inclusion: Skull bone defect OR orbital floor fracture

Investigational drug/treatment, dose and mode of administration: FRC implant Comparative drug(s)/placebo/treatment, dose and mode of administration: -

Duration of treatment: 2 years of follow-up

Assessments:

Clinical outcome and radiologic assesment Functional and aesthetic outcome with Visual Analog Scale (VAS). Pain assessment with VAS.

Statistical methods:

Adequate statistical methods for publishing in international peer-reviewed journals.

Conditions

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Cranial Bone Defect Orbital Base Fracture

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Skull bone reconstruction

Patients with skull bone defect

Group Type EXPERIMENTAL

FRC implant reconstruction

Intervention Type DEVICE

A cranioplasty with the FRC implant is performed.

Orbital floor defect

Patients with orbital floor defect

Group Type EXPERIMENTAL

FRC implant reconstruction

Intervention Type DEVICE

The orbital floor fracture is reconstructed with the FRC implant.

Interventions

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FRC implant reconstruction

A cranioplasty with the FRC implant is performed.

Intervention Type DEVICE

FRC implant reconstruction

The orbital floor fracture is reconstructed with the FRC implant.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Study arm 1:

* patients with skull bone defect
* reconstruction indications fullfilled

Study arm 2:

* patients with orbital floor defect
* reconstruction indication fullfilled

Exclusion Criteria

* if informed consent cannot be obtained
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Oulu University Hospital

OTHER

Sponsor Role collaborator

Turku Clinical Biomaterials Centre

UNKNOWN

Sponsor Role collaborator

Turku University Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kalle J Aitasalo, Professor

Role: PRINCIPAL_INVESTIGATOR

Turku University Hospital

Locations

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Department of Otorhinolaryngology

Turku, N/A = Not Applicable, Finland

Site Status

Countries

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Finland

Other Identifiers

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T97/2011

Identifier Type: -

Identifier Source: org_study_id

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