Implication of Left veNtricle Vortex Flow Guided aNticOagulation Therapy for preVenting Apical Thrombus Formation In Patients With Acute myOcardial infarctioN: Multicenter Prospective Randomized Clinical Trial; INNOVATION Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

111 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-02-29

Study Completion Date

2015-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Implication of left veNtricle vortex flow guided aNticOagulation therapy for preVenting Apical Thrombus formation In patients with acute myOcardial infarctioN: Multicenter Prospective Randomized Clinical Trial; INNOVATION study

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death

NCT02845531

Angina Pectoris, Variant Sudden Cardiac Death

RECRUITING PHASE4

Remote Ischemic Preconditioning Induces Myocardial RISK Signaling Pathway in Patients Undergoing Valvular Heart Surgery

NCT01946087

Patients With Elective Aortic Valve Replacement

COMPLETED PHASE4

Induced Angiogenesis by Genic Therapy in Advanced Ischemic Cardiomyopathy

NCT00744315

Ischemic Cardiopathy

UNKNOWN PHASE2

CryoValve® SG Aortic Human Heart Valve Combination Study

NCT01236469

Aortic Valve Stenosis Aortic Valve Insufficiency

COMPLETED

Medical Versus Surgical Management of Moderate Mitral Regurgitation Following Percutaneous Coronary Intervention

NCT01156441

Myocardial Infarction Mitral Regurgitation

WITHDRAWN PHASE1/PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Apical Thrombus Formation Acute Myocardial Infarction

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Low risk group (A)

(A)Vortex depth≥0.45

No interventions assigned to this group

High risk group 1 (B)

(B)Vortex depth\<0.45 with anticoagulation

No interventions assigned to this group

High risk group 2 (C)

(C)Vortex depth \<0.45 without anticoagulation

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patient is ≥ 30 years old
2. Acute anterior wall myocardial infarction showing akinetic or dyskinetic apical wall motion abnormalities on an initial transthoracic echocardiogram
3. Left ventricular ejection fraction less than 40%

Exclusion Criteria

1. Prior history of myocardial infarction
2. Chronic medication with Coumadin
3. Contraindication of contrast echocardiography
4. Significant atrial or ventricular arrhythmia
5. Valvular heart disease more than moderate degree
6. Decompensated heart failure
7. Very poor echo window, which cannot evaluate the presence of apical thrombus

Minimum Eligible Age

30 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No