Investigating Hereditary Cardiac Disease by Reprogramming Skin Cells to Heart Muscle

NCT ID: NCT01865981

Last Updated: 2020-07-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-06-30

Study Completion Date

2017-06-01

Brief Summary

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Hereditary cardiac arrhythmias (genetically caused disturbances of heart rhythm) are life threatening conditions affecting otherwise healthy young individuals. Due to the inaccessibility of heart tissue, the abnormal electrical current(s) in the heart cells causing the rhythm disturbance can be difficult to study in detail and therefore in many cases remain untreatable. The investigators propose to study heart cell electrical function from such patients by reprogramming skin cells to become stem cells and then differentiating them to heart muscle cells.

The hypothesis of the study is that the differentiated cardiac cells will display electrical abnormalities dependent on the mutation causing the disease. These abnormalities can therefore provide a clue as to the nature of the mutation causing the disease or information about its effective management

Detailed Description

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Conditions

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Eletrophysiology of iPS-derived Cardiomyocytes

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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Hereditary VF

Patients with hereditary ventricular fibrillation, negative for known mutations

No interventions assigned to this group

Brugada

Patients suffering from Brugada syndrome

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Clinical features of Brugada Syndrome (ECG findings)
* mutation positive or mutation negative
* Idiopathic ventricular fibrillation

Exclusion Criteria

* not able to give informed consent
* Age less than 18 years
* clinical diagnosis ambiguous
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Dundee

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marios P Stavridis, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Dundee

Locations

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University of Dundee

Dundee, Angus, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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T13/21

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2012CA04

Identifier Type: -

Identifier Source: org_study_id

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