Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-10-31

Study Completion Date

2011-12-31

Brief Summary

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The aim of this study is the identification of familial congenital arrhythmogenic disorders and their clinical follow-up.

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Detailed Description

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Molecular genetic screening in patients with:

* supraventricular
* ventricular arrhythmia
* syncopes of unknown origin and/or suspicion of an arrhythmogenic origin
* family members of patients with sudden cardiac death and aborted sudden cardiac death

Examination of patients includes routine testing like electrocardiogram (ECG), sequential ECGs, exercise testing, invasive electrophysiological stimulation, cardiac magnetic resonance imaging, intravenous drug challenge for identification/exclusion of eg Brugada syndrome. Examples are patients with Long QT Syndrome, Short QT Syndrome, Brugada Syndrome, familial atrial fibrillation, WPW-syndrome, arrhythmias due to familial hypertrophic cardiomyopathy or arrhythmogenic right ventricular dysplasia. Blood samples are taken for further molecular genetic screening.

Conditions

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Long QT Syndrome Hypertrophic Cardiomyopathy Arrhythmogenic Right Ventricular Dysplasia

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients with a history of syncope, abnormal ECG and suspicion of an arrhythmogenic disease
* Patients with long QT syndrome
* Patients with short QT syndrome, shortened QT intervals, borderline shortened QT intervals
* Patients with Brugada syndrome
* Patients with hypertrophic cardiomyopathy
* Patients with arrhythmogenic right ventricular dysplasia