Influence of Central Sensitization on Efficacy of Patient-controlled Epidural Analgesia in Osteoarthritis Patients Undergoing Total Knee Replacement

NCT ID: NCT01863342

Last Updated: 2013-05-27

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 98 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-05-31
• Study Completion Date: 2014-05-31

Brief Summary

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central sensitization. The degenerative joint disease, osteoarthritis, with characteristic destruction of cartilage and alteration in bone is a very common cause of chronic pain. The degree of pain does not always correlate with the extent of joint damage or presence of active inflammation raising the possibility that there may be a central component to the pain. The central sensitization inventory (CSI) is a new self-report screening instrument to measure the degree of central sensitization, and to help identify patients with central sensitivity syndromes. The aim of this investigation is to evaluate the influence of preoperative central sensitization, which represented by CSI score, on postoperative pain score in osteoarthritis patients undergoing total knee replacement who receiving patient-controlled epidural analgesia.

Conditions

Knee Osteoarthritis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

CSI score < 40

CSI cutoff value\<40

CSI score < 40

Intervention Type: PROCEDURE

Group 2: CSI score ≥ 40

CSI cutoff value≥40

CSI score ≥ 40

Intervention Type: PROCEDURE

Interventions

CSI score < 40

Intervention Type: PROCEDURE

CSI score ≥ 40

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Aged 20 to 80 years osteoarthritis patients undergoing total knee replacement under spinal anesthesia, and who receiving postoperative epidural PCA

Exclusion Criteria

• refusal
• coagulopathy
• neurologic deficit
• preoperative opioids medication
• recent analgesics change

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Yonsei University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine

Seoul, Seoul, South Korea

Site Status: RECRUITING

Countries

South Korea

Central Contacts

Shin Hyung Kim, MD

Role: CONTACT

tessar@yuhs.ac

82-2-2227-3556

Facility Contacts

Shin Hyung Kim, MD

Role: primary

tessar@yuhs.ac

82-2-2227-3556

Other Identifiers

4-2013-0127

Identifier Type: -

Identifier Source: org_study_id