Pharmacokinetic Interactions of Losartan and Hydrochlorothiazide
NCT ID: NCT01858623
Last Updated: 2013-05-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
18 participants
INTERVENTIONAL
2013-02-28
2013-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
NONE
Study Groups
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Losartan / Hydrochlorothiazide100 mg/25mg
Losartan / Hydrochlorothiazide100 mg/25mg fixed dose combination
Losartan/hydrochlorothiazide
Losartan 100 mg
Losartan 100 mg alone
Losartan
hydrochlorothiazide 25 mg
hydrochlorothiazide 25 mg alone
Hydrochlorothiazide
Interventions
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Losartan/hydrochlorothiazide
Losartan
Hydrochlorothiazide
Eligibility Criteria
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Inclusion Criteria
* Who had passed all the screening parameters
Exclusion Criteria
* If they showed a sitting SBP of \>140 or \<100 mmHg, DBP \> 90 or \<60mm Hg, or a pulse rate of \> 95 or \< 50 beats/min at screening
* The use of any prescription drug within the previous month or use of any over-the-counter medication within the past 14 days
* A history of blood dyscrasias
* A history of alcohol or drug abuse within the past year
* Donation of blood during the 8 weeks prior to the study or plans to donate blood during or within 8 weeks of completing the study
* Unable to tolerate vein puncture and multiple blood samplings
* Any surgical/medical condition that might alter drug absorption, distribution, metabolism, or excretion
18 Years
45 Years
MALE
Yes
Sponsors
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Damanhour University
OTHER
Responsible Party
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Sally Helmy, PhD, CPHQ
Lecturer of Pharmaceutics, Faculty of Pharmacy
Other Identifiers
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PPT5
Identifier Type: -
Identifier Source: org_study_id
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