Comparison of Effects Between Amlodipine and Hydrochlorothiazide in Combination With Losartan on 24-hr Central Blood Pressure in Hypertensive Patients
NCT ID: NCT02294539
Last Updated: 2017-03-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
231 participants
INTERVENTIONAL
2014-08-31
2016-05-18
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Losartan 50mg/amlodipine 5mg
Once daily, 1T, PO medication
Losartan 50mg/Hydrochlorothiazide 12.5mg
once daily, 1T, PO medication
Losartan 100mg/amlodipine 5mg
Once daily, 1T, PO medication
Losartan 100mg/Hydrochlorothiazide 25mg
once daily, 1T, PO medication
Losartan50 mg/Hydrochlorothiazide12.5 mg
Once daily, 1T, PO medication
Losartan 50mg/amlodipine 5mg
once daily, 1T, PO medication
Losartan100 mg/Hydrochlorothiazide25 mg
Once daily, 1T, PO medication
Losartan 100mg/amlodipine 5mg
once daily, 1T, PO medication
Interventions
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Losartan 50mg/amlodipine 5mg
once daily, 1T, PO medication
Losartan 100mg/amlodipine 5mg
once daily, 1T, PO medication
Losartan 50mg/Hydrochlorothiazide 12.5mg
once daily, 1T, PO medication
Losartan 100mg/Hydrochlorothiazide 25mg
once daily, 1T, PO medication
Other Intervention Names
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Eligibility Criteria
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Exclusion Criteria
\- msDBP≥110mmHg or ms SBP ≥ 180mmHg at the screening and randomization visit
19 Years
80 Years
ALL
No
Sponsors
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Hanmi Pharmaceutical Company Limited
INDUSTRY
Chong-Jin Kim
OTHER
Responsible Party
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Chong-Jin Kim
Chairman of Cardiovascular Center
Principal Investigators
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Chong-Jin Kim
Role: PRINCIPAL_INVESTIGATOR
Kyung Hee University Hospital at Gangdong
Locations
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Kyung Hee University Hospital at Gangdong
Seoul, , South Korea
Countries
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References
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Cho EJ, Lee HY, Sung KC, Park S, Sohn IS, Park CG, Choi DJ, Ha JW, Ahn YK, Shin J, Hong SJ, Kim SK, Chung WJ, Yoo BS, Hong TJ, Youn HJ, Cho MC, Chae SC, Kim YJ, Kim CJ. Comparison of 24-Hour Ambulatory Central Blood Pressure Reduction Efficacy Between Fixed Amlodipine or Up-Titrated Hydrochlorothiazide Plus Losartan: The K-Central Study. Am J Hypertens. 2019 Sep 24;32(10):992-1002. doi: 10.1093/ajh/hpz050.
Oh GC, Lee HY, Chung WJ, Youn HJ, Cho EJ, Sung KC, Chae SC, Yoo BS, Park CG, Hong SJ, Kim YK, Hong TJ, Choi DJ, Hyun MS, Ha JW, Kim YJ, Ahn Y, Cho MC, Kim SG, Shin J, Park S, Sohn IS, Kim CJ. Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active-controlled, phase 4, randomized trial. Clin Hypertens. 2017 Sep 4;23:18. doi: 10.1186/s40885-017-0074-0. eCollection 2017.
Other Identifiers
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KSH_AMST
Identifier Type: -
Identifier Source: org_study_id
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