Combine TACE and RFA Versus RFA Monotherapy in Unilobar HCC of 3.1 to 7 cm Patient

NCT ID: NCT01858207

Last Updated: 2013-05-23

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-01-31
• Study Completion Date: 2014-12-31

Brief Summary

Abstract of Research Proposal Radiofrequency ablation (RFA) has been proved to be a curative treatment with minimal invasiveness and high efficacy for small hepatocellular carcinoma (HCC) that is generally defined as maximal diameter no larger than 3cm. RFA can achieve a rate of complete necrosis as 80-100% in small HCC. However, the rate will drop to 71% in HCC of 3.1-5cm and 25% for HCC larger than 5cm。This is due to the relative hypervascularity for the bigger tumor and it will induce heat sink that leading to less effect of ablation. Therefore, transcatheter chemoembolization (TACE) before RFA may reduce the vascularity and enhance the effect of subsequent RFA. Moreover, pre-RF TACE will reduce the tumor size and the subsequent RFA will be more effective than RFA alone. In retrospective studies, Kitamoto M et al showed that tumor necrosis diameter was larger in TACE and RFA combination therapies compared to RFA mono-therapy; Yamakado K et al showed that TACE and RFA combination therapies in HCC (maximal diameter up to 12 cm) achieved 100% complete necrosis, 0% local recurrence rate and 93% of 2-year survival rate. Nevertheless, only one randomized trial in intermediate size HCC (3-5cm in diameter) showed that TACE and RFA combination therapies achieved a significant higher rate of complete necrosis, technique success, fewer treatment sessions to achieve complete necrosis and lower local recurrence but non-significant difference in 3-year survival rate. Therefore, based on the limited studies, combine TACE and RFA may achieve better effects than RFA mono-therapy in HCC larger than 3cm. However, repeat TACE may induce some complications such as HBV reactivation, hepatitis or even liver decompensation. Moreover, novel RFA using simultaneous multiple RFA probes with switching RF controller may achieve a better effects and shorter ablation time than sequential RFA with single electrode. Thus, is it still necessary using TACE and RFA combination therapies for HCC >3cm when application of novel switching RF controller? The aim of the current study is to conduct a RCT comparing combine TACE and RFA compared to RFA mono-therapy by using simultaneous multiple electrodes and switching RF controller in uni-lobar HCC of 3.1-7cm. The rate of complete necrosis, technique success, sessions to achieve CN, local tumor progression, survival rate and major complications will be analyzed. Investigators cannot expect which one is better, safer before the achievement of the study.

Detailed Description

Specific Aims:

The aim of the current study is to compare TACE and RFA combination therapies with RFA mono-therapy by using simultaneous multiple electrodes and switching RF controller in the treatment of uni-lobar HCC of 3.1 to 7cm. The rate of complete necrosis (CN), technique success, sessions to achieve CN, local tumor progression, survival rate and major complications will be analyzed.

Background:

HCC is 4th mostly common malignancy worldwide and the leading cause of cancer-death in Taiwan.

Surveillance programs can detect HCC at early stage. Surgical resection, liver transplantation and local ablation are currently considered as curative treatment modalities for early stage HCC. However, only 10-30% of early stage HCC is suitable for resection due to poor liver reserve, co-morbidity and shortage of liver donor. Therefore, local ablation plays an important role in the treatment of unresectable or resectable early-stage HCC. Among the various local ablative modalities, radiofrequency ablation (RFA) has been proved to be a curative treatment with minimal invasiveness and high efficacy for small HCC that is generally defined as maximal diameter no larger than 3cm. RFA can achieve a rate of complete necrosis as 80-100% in small HCC. However, the rate will drop to 71% in HCC of 3.1-5cm and 25% for HCC > 5cm。 The difference is due to the relative hypervascularity for the bigger tumor and it will induce heat sink that leading to less effect of ablation. Therefore, transcatheter chemoembolization (TACE) before RFA may reduce the vascularity and enhance the effect of subsequent RFA. Moreover, pre-RF TACE will reduce the tumor size and the subsequent RFA to unembolized viable tumor will be more effective than RFA alone. In retrospective studies, Kitamoto M et al showed that tumor necrosis diameter was larger in combine TACE and RFA compared to RFA monotherapy; Yamakado K et al showed that combine TACE and RFA in HCC (maximal diameter up to 12 cm) achieved 100% complete necrosis, 0% local recurrence rate and 93% of 2-year survival rate. Nevertheless, only one randomized trial in intermediate size HCC (3-5cm in diameter) showed that combine TACE and RFA achieved a significant higher rate of technique success, fewer treatment sessions and lower local recurrence but non-significant in 3-year survival rate. Therefore, based on the limited studies, combine TACE and RFA may achieve better effects than RFA mono-therapy in HCC larger than 3cm. However, repeat TACE may induce some complications such as HBV reactivation, hepatitis or even liver decompensation. Moreover, novel RFA using simultaneous multiple RFA probes with switching RF controller may achieve a better effects and shorter ablation time than sequential RFA with single electrode. Thus, is it still necessary using TACE and RFA combination therapies for HCC > 3cm when application of novel switching RF controller? aim of the current study is to conduct a RCT comparing combine TACE and RFA compared to RFA mono-therapy by using simultaneous multiple electrodes and switching RF controller in uni-lobar HCC of 3.1-7cm. The rate of complete necrosis, sessions to achieve CN, primary technique effectiveness (i.e. achievement of complete necrosis after maximum of 3 treatment sessions), local tumor progression, survival rate and major complications will be analyzed.

Conditions

Hepatocellular Carcinoma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

TACE+ RFA

This arm will be conventional TACE(Transcatheter Arterial Chemoembolization) plus RFA(radiofrequency ablation.

use intra-injection of lipiodol mized with doxorubicin when the catheter was placed in the superselective location very close to the tumor.

Group Type: ACTIVE_COMPARATOR

Transcatheter Arterial Chemoembolization

Intervention Type: PROCEDURE

traditional TACE, conventional TACE

Doxorubicin

Intervention Type: DRUG

TACE will be done according to the current method in our center. We use intra-injection of lipiodol mized with doxorubicin when the catheter was placed in the superselective location very close to the tumor. Gelfoam sponge was then injected to temporarily occlude the arterial blood flow.

RFA

Recent advances in local ablation are aimed to expand the ablation size (\> 3cm in diameter) in a minimal session by utilizing the switching RF controller and simultaneous 2 or 3 RF electrodes placement. The procedure of RFA was according to manufacture algorithm. RFA was performed within 7 days after TACE because the embolization effect in reducing blood flow will be not evident afterwards.

Group Type: ACTIVE_COMPARATOR

Radiofrequency ablation

Intervention Type: PROCEDURE

simultaneous multiple electrodes and switching RF controller

Interventions

Transcatheter Arterial Chemoembolization

traditional TACE, conventional TACE

Intervention Type: PROCEDURE

Radiofrequency ablation

simultaneous multiple electrodes and switching RF controller

Intervention Type: PROCEDURE

Doxorubicin

TACE will be done according to the current method in our center. We use intra-injection of lipiodol mized with doxorubicin when the catheter was placed in the superselective location very close to the tumor. Gelfoam sponge was then injected to temporarily occlude the arterial blood flow.

Intervention Type: DRUG

Other Intervention Names

TACE, Chemoembolization; RFA

Eligibility Criteria

Inclusion Criteria

• Age >18 years;
• Unresectable HCC or patients with resectable HCC but not appropriate for resection;.
• Tumor stage: single tumor with 3.1-7cm in diameter, or multiple (maximum 3) tumors with at least one over 3cm but only one of the multiple tumors larger than 5cm for concerning too prolonged time of RFA. All the target tumors are located in single lobe.
• The lesion should be detected on ultrasonography;
• The divergence of the hepatic artery was suitable for TACE;
• Absence of portal and venous thrombosis, extrahepatic metastases, or uncontrollable ascites;
• Patients in Child-Pugh grade A or B;
• Eastern Cooperative Oncology Group performance status score of 2 or less;
• Patient has signed consent form regarding participation in the study.

Exclusion Criteria

• Patients had previously received any treatment for HCC;
• Patients with known renal or cardiovascular disease before TACE;
• Child-Pugh grade C cirrhosis, prior decompensation and history of encephalopathy before TACE
• Pregnancy or plan to pregnant in the subsequent study period (1 to 2 years)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shi-Ming Lin

OTHER

Sponsor Role: lead

Responsible Party

Shi-Ming Lin

Professor, MD

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Shi-Ming Lin, MD

Role: PRINCIPAL_INVESTIGATOR

Chang Gung Medical Foundation

Locations

Chang Gung Memorial Hospital, Lin-Kuo

Taoyuan District, , Taiwan

Site Status: RECRUITING

Countries

Taiwan

Central Contacts

Shi-Ming Lin, MD.

Role: CONTACT

lsmpaicyto@cgmh.org.tw

886-3-3281200 ext. 8107

Facility Contacts

Yu-Ray Chen

Role: primary

+886-2-27135211

Other Identifiers

CMRPG3B0121

Identifier Type: -

Identifier Source: org_study_id