Acceptability of an Out-patient Regimen of Medical Abortion With Mifepristone and 800 Mcg Misoprostol Administered at 78-84 Days Gestation

NCT ID: NCT01856985

Last Updated: 2013-10-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Study Completion Date

2013-09-30

Brief Summary

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These pilot studies are designed as open label studies to investigate the acceptability of 200 mg mifepristone followed 24-48 hours later by either 1) 800 µg misoprostol administered buccally or 2) 800 µg misoprostol administered sublingually for medical abortion in gestations 78-84 days' LMP. They will be done consecutively.

Findings from the pilot studies will guide the development of a larger, multi-site study to investigate the efficacy of outpatient medical abortion regimens for women with gestations from 78 - 84 days LMP. In that end, the pilots seek to collect information on the acceptability of an outpatient medical abortion regimen of 200 mg oral mifepristone followed by either 800 mcg misoprostol delivered either buccally or sublingually safe acceptable? Women's rating of the tolerability of any side effects will also be documented.

Detailed Description

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Conditions

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Medical Abortion

Keywords

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Medical abortion Misoprostol Mifepristone

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Misoprostol at clinic

Eligible women will receive 200 mg mifepristone to be administered at home or at the clinic and will receive either 800 µg misoprostol buccally (study 1) or 800 µg misoprostol sublingually (study 2) to self administer at home.

Participants will be asked to return to the hospital 14 days later for a follow-up visit.

Group Type EXPERIMENTAL

Misoprostol

Intervention Type DRUG

Mifepristone

Intervention Type DRUG

Interventions

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Misoprostol

Intervention Type DRUG

Mifepristone

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Seeking abortion services
* Have an intrauterine pregnancy 78 days through 84 days' LMP
* Be willing and able to sign consent forms
* Agree to comply with study procedures and visit schedule
* Be living with 30 minutes from the hospital
Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Gynuity Health Projects

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Beverly Winikoff, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

Gynuity Health Projects

Jennifer Blum, MPH

Role: PRINCIPAL_INVESTIGATOR

Gynuity Health Projects

Nguyen Thu Nhu Ngoc, MD

Role: PRINCIPAL_INVESTIGATOR

Center for Research and Consultancy in Reproductive Health

Dina F Abbas

Role: PRINCIPAL_INVESTIGATOR

Gynuity Health Projects

Locations

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Hung Vuong Hospital

Ho Chi Minh City, , Vietnam

Site Status

Countries

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Vietnam

Other Identifiers

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1010

Identifier Type: -

Identifier Source: org_study_id