A Randomized Trial of Buccal Compared to Oral Misoprostol Following Mifepristone for Medical Abortion up to 63 Days LMP

NCT ID: NCT00386867

Last Updated: 2007-06-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2007-03-31

Brief Summary

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This open-label, randomized study will compare the efficacy, safety, and acceptability of mifepristone 200 mg followed in 24-36 hours either by buccal (i.e., in the cheeks) or oral misoprostol 800 mcg for termination of pregnancy in women up to 63 days L.M.P.

Detailed Description

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Conditions

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Abortion, Induced

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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800 mcg misoprostol via oral or buccal administration

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* be willing and able to sign consent forms;
* be eligible for medical abortion according to clinician's assessment;
* be willing to undergo a surgical completion if necessary;
* have ready and easy access to a telephone and emergency transportation;
* speak English, Spanish, or have a translator available to translate for all study procedures; and,
* agree to comply with the study procedures and visit schedule.

Exclusion Criteria

* Confirmed or suspected ectopic pregnancy or undiagnosed adnexal mass;
* IUD in place;
* Chronic renal failure;
* Concurrent long-term corticosteroid therapy;
* History of allergy to mifepristone, misoprostol or other prostaglandin;
* Hemorrhagic disorders or concurrent anticoagulant therapy;
* Inherited porphyrias; or
* Other serious physical or mental health conditions.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Gynuity Health Projects

OTHER

Sponsor Role lead

Principal Investigators

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Beverly Winikoff, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

Gynuity Health Projects

Ilana Dzuba, MHS

Role: STUDY_DIRECTOR

Gynuity Health Projects

Locations

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Family Planning Associates Medical Group

Chicago, Illinois, United States

Site Status

Planned Parenthood League of Massachusetts (Boston clinic)

Boston, Massachusetts, United States

Site Status

Columbia University Medical Center, Division of Obstetrics & Gynecology

New York, New York, United States

Site Status

Institute for Urban Family Health

New York, New York, United States

Site Status

Parkmed

New York, New York, United States

Site Status

University of Pittsburgh, Division of Obstetrics, Gynecology and Reproductive Sciences

Pittsburgh, Pennsylvania, United States

Site Status

Whole Women's Health

Austin, Texas, United States

Site Status

Planned Parenthood

Waco, Texas, United States

Site Status

Countries

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United States

References

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Winikoff B, Dzuba IG, Creinin MD, Crowden WA, Goldberg AB, Gonzales J, Howe M, Moskowitz J, Prine L, Shannon CS. Two distinct oral routes of misoprostol in mifepristone medical abortion: a randomized controlled trial. Obstet Gynecol. 2008 Dec;112(6):1303-1310. doi: 10.1097/AOG.0b013e31818d8eb4.

Reference Type DERIVED
PMID: 19037040 (View on PubMed)

Related Links

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Other Identifiers

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1.1.3

Identifier Type: -

Identifier Source: org_study_id