TI-001 (Intranasal Oxytocin) for Treatment of High Frequency Episodic Migraine and Chronic Migraine

NCT ID: NCT01839149

Last Updated: 2016-05-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-05-31

Study Completion Date

2016-01-31

Brief Summary

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This study evaluates the use of oxytocin, given as a nasal spray, for treatment of high frequency episodic migraine and chronic migraine.

Detailed Description

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Conditions

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High Frequency Episodic Migraine and Chronic Migraine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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TI-001 (intranasal oxytocin)

TI-001 is intranasal oxytocin

Group Type EXPERIMENTAL

TI-001

Intervention Type DRUG

TI-001 is intranasal oxytocin

Placebo

Placebo for TI-001 is the same intranasal formulation without oxytocin

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

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TI-001

TI-001 is intranasal oxytocin

Intervention Type DRUG

Placebo

Intervention Type DRUG

Other Intervention Names

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Intranasal oxytocin

Eligibility Criteria

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Inclusion Criteria

1\. Men and women, aged 18 to 65 years with primary diagnosis of high frequency episodic migraine or chronic migraine.

Exclusion Criteria

1. Known allergy to oxytocin
2. History of addictive behavior (eg, alcoholism, drug abuse) or severe mood disorder
3. History of clinically significant, functionally impairing cardiovascular or pulmonary disease or any other disease that might confound study results
4. Have basilar or hemiplegic migraines
5. Have substantial cognitive or memory impairment due to any cause (eg, Alzheimer's or dementia)
6. Have a nasal obstruction due to any cause
7. Are pregnant or breast feeding
8. Require ongoing use of steroidal or nonsteroidal anti-inflammatory drugs
9. Are unable or unwilling to provide informed consent or to follow study procedures
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Trigemina, Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Raquel Izumi, PhD

Role: STUDY_DIRECTOR

Trigemina, Inc

Locations

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Fitzroy, , Australia

Site Status

Prahran, , Australia

Site Status

Sherwood, , Australia

Site Status

Santiago, , Chile

Site Status

Tauranga, , New Zealand

Site Status

Wellington, , New Zealand

Site Status

Countries

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Australia Chile New Zealand

Other Identifiers

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TRIG-05

Identifier Type: -

Identifier Source: org_study_id

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