Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft
NCT ID: NCT01838356
Last Updated: 2018-01-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
169 participants
OBSERVATIONAL
2012-09-30
Brief Summary
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The main hypothesis of the study states that pre-surgical blood flow in the brain will be an independent risk factor for depression after surgery after adjusting for other risk factors such as gender, pre-CABG depression, social support, medical comorbidity burden, socioeconomic status, and neuroticism.
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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No treatment.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Will be having CABG surgery at the Yale New Haven Hospital
* Be able to provide informed consent
* Have a household telephone
* A fluent English speaker, and possessing no communication barrier
* Be able to come to the study site or to have the study team come to his/her home.
* Has a family member or partner/ friend who could provide collateral information
Exclusion Criteria
* History of dementia diagnosis or cognitive impairment (CDR \>/= 1)
* Auditory or visual impairment that would interfere with study procedures
* Active alcohol or substance abuse problem based CAGE-AID (endorsing two or more items)
* History of Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, or any Psychotic Disorder by medical history or self-report.
* Presence of non-cardiovascular conditions likely to be fatal within 1 year
40 Years
ALL
No
Sponsors
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Yale University
OTHER
Responsible Party
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Locations
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Yale University School of Medicine
New Haven, Connecticut, United States
The Johns Hopkins University
Baltimore, Maryland, United States
Countries
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References
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Choi JJ, Kukla B, Walsh P, Oldham MA, Lee HB. Functional, cognitive, and cerebrovascular aspects of depression before coronary artery bypass graft surgery: Testing the vascular depression hypothesis. Int J Geriatr Psychiatry. 2023 Sep;38(9):e6000. doi: 10.1002/gps.6000.
Oldham MA, Hawkins KA, Yuh DD, Dewar ML, Darr UM, Lysyy T, Lee HB. Cognitive and functional status predictors of delirium and delirium severity after coronary artery bypass graft surgery: an interim analysis of the Neuropsychiatric Outcomes After Heart Surgery study. Int Psychogeriatr. 2015 Dec;27(12):1929-38. doi: 10.1017/S1041610215001477. Epub 2015 Oct 2.
Other Identifiers
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1202009664
Identifier Type: -
Identifier Source: org_study_id
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