Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression

NCT ID: NCT00818506

Last Updated: 2012-11-21

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 55 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2009-03-31
• Study Completion Date: 2012-06-30

Brief Summary

Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD. Among other mechanisms atherosclerosis is believed to play a central role regarding these notable associations between depression and CAD. Moreover, patients with late onset major depression have an increased number of small lesions found in the white matter of the brain, the so-called white matter lesions. The main goal of this project is to examine if CAD is associated with depression and/or white matter lesions. CAD is evaluated using coronary CT angiography. Depression is evaluated using a semi-structured diagnostic interview. White matter lesions are quantified using cerebral magnetic resonance.

Conditions

Depression; Major Depressive Disorder; Cardiovascular Disease; Coronary Artery Disease

Keywords

Depression; Major depressive disorder; Coronary artery disease; White Matter Hyperintensities; White Matter Lesions; Coronary artery calcification

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Late onset MDD

Patients with major depressive disorder between 50 and 70 years of age that did not suffer from depression before the age of 50.

No interventions assigned to this group

Controls

Healthy controls (matched for age, sex, and tobacco use status)

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Submitted to psychiatric hospital, district psychiatry or private psychiatrist because of major depressive disorder.
• Meets the criteria for Major Depressive Disorder, Single Episode as defined in the Diagnostic and Statistical Manual, fourth edition (DSM-IV) and the International Classification of Diseases (ICD-10).
• Age 50-70 years.
• Written informed consent.
• Caucasian.

Exclusion Criteria

• Known, or anamnestic/objective signs of, organic brain disease.
• Organic, including symptomatic, mental disorders as (ICD-10: F00-F09).
• Dependence syndrome within the last 5 years (ICD-10: F1x.2) or current harmful use (ICD-10: F1x.1) of alcohol or other psychoactive substances.
• Schizophrenia, schizotypal and delusional disorders (ICD-10: F20-F29).
• Subject to force of law according to the danish law on psychiatry.
• Present risk of suicide.
• Previous cranial trauma resulting in unconsciousness for more than 2 minutes.
• Medical history of renal failure.
• Other conditions which contraindicate specific procedures in the project.
• Other conditions deemed to prevent the subject from completing the examination program.
• Does not want to participate.

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

The Ministry of Science, Technology and Innovation, Denmark

OTHER_GOV

Sponsor Role: collaborator

Vejle Hospital

OTHER

Sponsor Role: collaborator

Danish National Research Foundation

OTHER

Sponsor Role: collaborator

Aarhus University Hospital

OTHER

Sponsor Role: collaborator

Augustinus Fonden

OTHER

Sponsor Role: collaborator

University of Aarhus

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Poul Videbech, Professor, M.D., Dr.Med.

Role: STUDY_DIRECTOR

Center of Psychiatric Research, Aarhus University Hospital

Locations

Center of Psychiatric Research, Aarhus University Hospital

Aarhus, , Denmark

Countries

Denmark

Other Identifiers

CPF-TAD-1

Identifier Type: -

Identifier Source: org_study_id