Treatment of Severe Depressive Illness by Targeted Brain Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Study Classification

OBSERVATIONAL

Study Start Date

2000-10-31

Study Completion Date

2010-04-30

Brief Summary

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This study will report on the outcome of a clinical program, operational since 1998, that has used surgery targeting an emotional pathway in the brain in the treatment of severe depressive illness that has failed to respond to all other available interventions. Benefit from surgery was anticipated on the basis that the lesion (bilateral anterior capsulotomy) is a well established surgical target for treating severe treatment resistant depression.

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Detailed Description

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Since 1998 bilateral anterior capsulotomy (BAC) has been available to patients in British Columbia Canada who have treatment refractory severe depressive illness. This study will report on the outcome of patients who have received this intervention. BAC is achieved by stereotactic radiofrequency lesioning. To date 8 patients have received BAC. For all patients there is follow-up data of at least 24 months. The purpose of this retrospective study is to report on the surgical protocol and to demonstrate the efficacy and safety of BAC in severe depression.

Conditions

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Major Depressive Disorder

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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1

All subjects who received BAC for treatment resistant depression between 2000 and 2009

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Severe treatment resistant depression of at least 5 years duration
* older than 18 years

Exclusion Criteria

* Comorbid organic mental disorder
* Delusional disorder
* Substance disorder
* Neurological disease
* Cluster B personality disorder

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Trevor Hurwitz

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR