Short-term Investigation of Resveratrol on Fat Metabolism in Morbidly Obese Women Undergoing Gastric Bypass Surgery
NCT ID: NCT01826279
Last Updated: 2014-01-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
16 participants
INTERVENTIONAL
2013-05-31
2014-08-31
Brief Summary
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The investigators hypothesize that resveratrol will:
* Decrease hepatic very-low-density-lipoprotein-triglyceride (VLDL-TG) secretion
* Decrease hepatic and adipose tissue VLDL-TG uptake
* Increase insulin sensitivity
The investigators will look at changes in:
* Lipid turnover (VLDL-TG kinetics, palmitate kinetics,calorimetry)
* VLDL-TG uptake in different tissues (subcutaneous femoral adipose tissue, subcutaneous abdominal adipose tissue, visceral adipose tissue and liver tissue)
* Insulin sensitivity (glucose kinetics during hyperinsulinaemic euglycaemic clamp)
* Regulation of liver fat handling
* Lipoprotein lipase activity and fat cell size (abdominal and femoral adipose tissue)
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
TRIPLE
Study Groups
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Resveratrol
Resveratrol 500mg 3 times daily for 1 month
Resveratrol
500mg 3 times daily for 1 month
Placebo
Placebo 1 tablet 3 times daily for 1 month
Placebo
1 placebo tablet 3 times daily for 1 month
Interventions
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Resveratrol
500mg 3 times daily for 1 month
Placebo
1 placebo tablet 3 times daily for 1 month
Eligibility Criteria
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Inclusion Criteria
* 25-60 years
* Obesity (BMI \> 35 kg/m2)
* Have at least one element of the metabolic syndrome either hypertension and/or hypercholesterolemia (high triglyceride, low HDL-cholesterol)
* Undergoing gastric bypass surgery
* Written informed consent
Exclusion Criteria
* May have arthrosis or depression
* Any present or previous malignancy
* History of smoking
* Alcohol dependency (more than 14 units of alcohol per week)
* Participation in studies with radioactive isotope within the last six months
* Hemoglobin under the normal range regarding to sex (under 7.3 mmol/l for women)
25 Years
60 Years
FEMALE
No
Sponsors
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The Ministry of Science, Technology and Innovation, Denmark
OTHER_GOV
University of Aarhus
OTHER
Responsible Party
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Principal Investigators
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Søren Nielsen, MD, associate professor, DMSc
Role: STUDY_CHAIR
Department of Endocrinology and Internal Medicine
Locations
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Department of Endocrinology and Internal Medicine
Aarhus C, , Denmark
Countries
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Other Identifiers
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M-20110172B
Identifier Type: -
Identifier Source: org_study_id
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