Cologne Cohort of Neutropenic Patients (CoCoNut)

NCT ID: NCT01821456

Last Updated: 2013-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100000 participants

Study Classification

OBSERVATIONAL

Study Start Date

1995-01-31

Study Completion Date

2050-12-31

Brief Summary

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The Cologne Cohort of Neutropenic Patients (CoCoNut) is a non-interventional cohort study assessing risk factors, interventions, and outcome of immunosuppressed patients with or without opportunistic infections.

Detailed Description

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This prospective cohort was established with the aim of a comprehensive data collection of all patients developing neutropenia after receiving chemotherapy for any kind of malignant disease, treated in the University Hospital of Cologne.

Conditions

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Hematological Malignancies Cancer Chemotherapy Neutropenia Immunosuppression

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Antiinfectives

To analyze the efficacy of antiinfectives at high risk patients

Antiinfectives

Intervention Type DRUG

To analyze to efficacy of (novel) drug therapies

Interventions

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Antiinfectives

To analyze to efficacy of (novel) drug therapies

Intervention Type DRUG

Other Intervention Names

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Antifungals, Antibacterials, Antivirals

Eligibility Criteria

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Inclusion Criteria

* immunosuppressed patients

Exclusion Criteria

* none
Minimum Eligible Age

1 Year

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital of Cologne

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University Hospital of Cologne

Cologne, North Rhine-Westphalia, Germany

Site Status RECRUITING

Countries

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Germany

Facility Contacts

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Jörg Janne Vehreschild, Dr. med.

Role: primary

+0049 (0)221 478-6494 ext. -6494

Oliver Andreas Cornely, Prof. Dr. med.

Role: backup

0049 (0)221 478-6494 ext. -6494

References

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Vehreschild JJ, Ruping MJ, Wisplinghoff H, Farowski F, Steinbach A, Sims R, Stollorz A, Kreuzer KA, Hallek M, Bangard C, Cornely OA. Clinical effectiveness of posaconazole prophylaxis in patients with acute myelogenous leukaemia (AML): a 6 year experience of the Cologne AML cohort. J Antimicrob Chemother. 2010 Jul;65(7):1466-71. doi: 10.1093/jac/dkq121. Epub 2010 Apr 21.

Reference Type RESULT
PMID: 20410061 (View on PubMed)

Vehreschild MJ, von Bergwelt-Baildon M, Tran L, Shimabukuro-Vornhagen A, Wisplinghoff H, Bangard C, Cornely OA, Vehreschild JJ. Feasibility and effectiveness of posaconazole prophylaxis in combination with micafungin bridging for patients undergoing allogeneic stem cell transplantation: a 6-yr analysis from the cologne cohort for neutropenic patients. Eur J Haematol. 2014 Nov;93(5):400-6. doi: 10.1111/ejh.12368. Epub 2014 May 26.

Reference Type DERIVED
PMID: 24798021 (View on PubMed)

Vehreschild MJ, Weitershagen D, Biehl LM, Tacke D, Waldschmidt D, Tox U, Wisplinghoff H, Von Bergwelt-Baildon M, Cornely OA, Vehreschild JJ. Clostridium difficile infection in patients with acute myelogenous leukemia and in patients undergoing allogeneic stem cell transplantation: epidemiology and risk factor analysis. Biol Blood Marrow Transplant. 2014 Jun;20(6):823-8. doi: 10.1016/j.bbmt.2014.02.022. Epub 2014 Mar 6.

Reference Type DERIVED
PMID: 24607558 (View on PubMed)

Other Identifiers

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!!SZINF2

Identifier Type: OTHER

Identifier Source: secondary_id

!SZINF2

Identifier Type: -

Identifier Source: org_study_id

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