Study of DA-9801 to Treat Diabetic Neuropathic Pain

NCT ID: NCT01813799

Last Updated: 2019-04-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

128 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-11-30

Study Completion Date

2013-07-31

Brief Summary

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This is a Phase II dose-ranging study to evaluate the effectiveness and safety of DA-9801 in the treatment of pain associated with diabetic neuropathy. Subjects will receive either 300mg, 600mg, 900mg or placebo, three times daily for eight weeks. During treatment, pain score by Likert numerical rating scale, Patient Global Impression of Improvement (PGI-I) and Change in Clinical Global Impression(CGI)are accessed to evaluate the effectiveness.

Detailed Description

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Conditions

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Diabetic Neuropathies

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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DA-9801 300mg

Group Type EXPERIMENTAL

DA-9801 300mg

Intervention Type DRUG

300mg of DA-9801 tablet is assigned at week 0 point and is taken for 8 continuous weeks, 3 times a day.

DA-9801 600mg

Group Type EXPERIMENTAL

DA-9801 600mg

Intervention Type DRUG

600mg of DA-9801 tablet is assigned at week 0 point and is taken for 8 continuous weeks, 3 times a day.

DA-9801 900mg

Group Type EXPERIMENTAL

DA-9801 900mg

Intervention Type DRUG

900mg of DA-9801 tablet is assigned at week 0 point and is taken for 8 continuous weeks, 3 times a day.

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo is assigned at week 0 point and is taken for 8 continuous weeks, 3 times a day.

Interventions

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DA-9801 300mg

300mg of DA-9801 tablet is assigned at week 0 point and is taken for 8 continuous weeks, 3 times a day.

Intervention Type DRUG

DA-9801 600mg

600mg of DA-9801 tablet is assigned at week 0 point and is taken for 8 continuous weeks, 3 times a day.

Intervention Type DRUG

DA-9801 900mg

900mg of DA-9801 tablet is assigned at week 0 point and is taken for 8 continuous weeks, 3 times a day.

Intervention Type DRUG

Placebo

Placebo is assigned at week 0 point and is taken for 8 continuous weeks, 3 times a day.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* the age of 20 \~ 70
* Type I or Type II Diabetes
* HbA1c ≤11%
* Patients with diabetic neuropathic pain for at least 3 months
* Patients corresponding to average pain level of 4 points or more for 24 hours evaluated with 11-point Likert scale

Exclusion Criteria

* neuropathic pain due to other causes or another stronger pain other than neuropathic pain
* abnormal in blood pressure, weight, ALT/AST, Serum creatinine
* positive reaction in HIV, HBV, or HCV
* experience of suicide try or Mental Illness Medical History
* BDI(Beck Depression Inventory) grade exceeding 21 points chronic alcohol abuse history
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dong-A ST Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bongyeon Cha, M.D.

Role: PRINCIPAL_INVESTIGATOR

The Catholic University of Korea

Hyeok Sang Gwon, M.D.

Role: PRINCIPAL_INVESTIGATOR

Catholic University Yeouido St. Mary's Hopspital

Inkyung Jeong, M.D.

Role: PRINCIPAL_INVESTIGATOR

Gangdong Kyunghee University Hospital

Ji Hyeon Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

Daegu Catholic University Medical Center

Jeong Guk Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Kyungpook National University Hospital

In Ju Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Busan National University Hospital

Young Min Cho, M.D.

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Chun Hee Jung, M.D.

Role: PRINCIPAL_INVESTIGATOR

Yonsei University Wonju Christian Hospital

Jyeong Hyeon Park, M.D.

Role: PRINCIPAL_INVESTIGATOR

Inje University

Mun Seok Nam, M.D.

Role: PRINCIPAL_INVESTIGATOR

Inha University Hospital

Dong Hyeok Cho, M.D.

Role: PRINCIPAL_INVESTIGATOR

Chonnam National University Hospital

Min Kyong Moon, M.D.

Role: PRINCIPAL_INVESTIGATOR

SMG-SNU Boramae Medical Center

Chong Hwa Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

Sejong General Hospital

Kwan Pyo Ko, M.D.

Role: PRINCIPAL_INVESTIGATOR

Jeju National University Hospital

Locations

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Chonbuk National University Hospital

Jeonju, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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DA9801_DN_II

Identifier Type: -

Identifier Source: org_study_id

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