A Study to Evaluate the Safety of DA-3030 and to Explore the Efficacy for Diabetic Neuropathic Pain

NCT ID: NCT01820715

Last Updated: 2013-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-30

Brief Summary

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A multi-centers, placebo-controlled, randomized, double-blinded, pilot clinical trial is designed to evaluate the safety of the DA-3030 injection and to explore the efficacy for Neuropathic pain.

Detailed Description

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Conditions

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Diabetic Neuropathy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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600㎍ of DA-3030 Injection

600㎍ of DA-3030 is injected once a day, for 5 continuous days.

Group Type EXPERIMENTAL

600㎍ of DA-3030 Injection

Intervention Type DRUG

Placebo

Placebo(a salin drip) is injected once a day, for 5 continuous days.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

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600㎍ of DA-3030 Injection

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 20≤ Age ≤ 70
* Diagnosed with Type I or Type II diabetes
* HbA1c ≤ 11%
* Patients with diabetic neuropathic pain for at least 3 months
* Patients corresponding to average pain level of 4 points or mor for 24 hours evaluated with 11-point Likert scale

Exclusion Criteria

* Neuropathic pain due to other causes
* Another stronger pain other than neuropathic pain
* Abnormality in blood pressure, weight
* Positive reaction in HIV, HBV or HCV
* A medical history of mental illness within 6 months
* The grade of BDI(Beck Depression Inventory) exceeds 21 points
* History of drug/alcohol abuse
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dong-A Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yoo Heon Ahn, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Hanyang University

Bong Yeon Cha, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Seoul St. Mary's Hospital, The Catholic University of Korea

Kyung Soo Ko, M.D, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Inje University

Tae Sun Park, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Chonbuk National University Hospital

Young Soo Park, M.D.,Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Hanyang University

Choon Hee Chung, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Wonju Christian Hospital

In Joo Kim, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Pusan National University Hospital

Locations

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Hanyang University Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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DA3030_DN_I (Version 3.4)

Identifier Type: -

Identifier Source: org_study_id