Treatment of Symptoms in Male Patients With Lower Urinary Tract Symptoms (LUTS) Predominant Storage Symptoms (Overactive Bladder Syndrome)

NCT ID: NCT01799902

Last Updated: 2013-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

86 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-12-31

Study Completion Date

2013-10-31

Brief Summary

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This study is a non interventional study where no investigational medicine is provided. Procedures and examination will follow the institution standard of care practice. The therapeutic approach will not be decided in advance by the protocol or influenced in any way by the protocol.

After standard evaluation the investigator will decide the treatment strategy and upon eligibility criteria met will propose subject to participate to the study. Informed consent will be collected for all subjects.

The study will consist of 3 possible observational visits; V1 (enrolment), V2 and V3 (follow up).

During all observational visits (V1, V2 and V3) the patient will complete the I-PSS (International Prostate Symptom Score) questionnaire including Quality Of Life (QOL) questionnaire and a Patient assessment of treatment benefit and satisfaction using a Visual Analogue Scale (VAS).

The patient will be asked to complete a voiding diary the first 3 days after Visit 1 (Baseline diary), 3 days before Visit 2 and again 3 days before Visit 3.

Prostate Specific Antigen (PSA) measurement- Uroflowmetry - Post Voiding Residual volume and Trans Rectal Ultra Sound data will be collected only if available.

During all observational visits (V1, V2 and V3) the investigator will complete the assessment of treatment benefit and satisfaction using a VAS.

Detailed Description

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Conditions

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Lower Urinary Tract Predominant Storage Symptoms

Keywords

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Observational Non-Interventional Prospective Phase IV Treatment Overactive Bladder Syndrome Solifenacin

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Male subjects with LUT predominant storage symptoms (OAB)

male subjects with Overactive Bladder Syndrome (OAB) being treated with solifenacin in monotherapy or combination

Solifenacin

Intervention Type DRUG

Oral

Interventions

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Solifenacin

Oral

Intervention Type DRUG

Other Intervention Names

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YM905, Vesicare®

Eligibility Criteria

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Inclusion Criteria

The following subjects can be included in this study if they answer the following criteria:

* they have been prescribed solifenacin 5-10mg according to Summary of Product Characteristics (SmPC).
* Subjects with diagnosed Lower Urinary Tract Symptoms (LUTS) with substantial storage disorder defined as urgency, and/or frequency and/or Urge Urinary Incontinence (UUI) at the discretion of the investigator.
* IPSS storage sub-score \> 8
* Subject expected to require at least 3 months treatment with solifenacin.

Exclusion Criteria

* Any reason which following current medical knowledge, physical condition of the patient and in the opinion of the investigator contraindicates administration of solifenacin to the subject, such as- signs and symptoms suggestive of urinary tract infection (confirmed by positive urine analysis).
* History of bladder obstruction not being adequately corrected.
* Anticipate or plan to participate in another study during study period of 12 weeks from study entry.
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Veeda Clinical Research

INDUSTRY

Sponsor Role collaborator

Astellas Pharma Europe B.V.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Astellas Pharma Europe B.V.

Locations

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ASZ

Aalst, , Belgium

Site Status

ZNA Stuyvenberg

Antwerp, , Belgium

Site Status

Erasme

Brussels, , Belgium

Site Status

UZ Brussel

Brussels, , Belgium

Site Status

Private practice

Brussels, , Belgium

Site Status

AZ St. Monica

Deurne, , Belgium

Site Status

UZ Antwerpen

Edegem, , Belgium

Site Status

Maria Middelares

Ghent, , Belgium

Site Status

Sint-Lucas

Ghent, , Belgium

Site Status

UZ Gent

Ghent, , Belgium

Site Status

AZ Groeninge

Kortrijk, , Belgium

Site Status

AZ Damiaan

Ostend, , Belgium

Site Status

AZ Oudenaarde

Oudenaarde, , Belgium

Site Status

H.Hart Roeselaere

Roeselaere, , Belgium

Site Status

AZ Sint Elisabeth

Zottegem, , Belgium

Site Status

Countries

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Belgium

Other Identifiers

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BE-11-VES-01

Identifier Type: -

Identifier Source: org_study_id