Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population

NCT ID: NCT01798225

Last Updated: 2018-10-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 113 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-12-31
• Study Completion Date: 2010-01-31

Brief Summary

Our overall hypothesis is that treatment of periodontal disease will produce better diabetes glycemic control (glycated hemoglobin A1c, or HbA1c) and reduced levels of the catalytically active form of matrix metalloproteinase (aMMP-8) in the Gullah African American type 2 diabetes patients living on the Sea Islands of the South Carolina coast. The gingival crevicular fluid (GCF) aMMP-8 levels will be measured through a site-specific, novel noninvasive technique allowing the pathophysiological status of the periodontium tissue to be monitored. The investigators will conduct an interventional study on this population with minimal genetic admixture.

Detailed Description

Specific Aim 1: To ascertain the rate of periodontal disease progression on poorly controlled Type 2 diabetic Gullah African American patients as compared to well-controlled Gullah African American patients. The host inflammatory response appears to be the critical determinant for susceptibility and severity of marginal periodontitis especially in systemically compromised individuals13, with diabetic status perhaps increasing host susceptibility to periodontal infection due to impaired immune response14. Patients have been evaluated 6 months to one year prior to periodontal therapy (this evaluation is connected to a previous COBRE project entitled "Epidemiological Study of Periodontal Disease and Diabetes" by Dr. J. Fernandes). A reevaluation will be made at the time of periodontal therapy. Clinical periodontal parameters and HbA1c levels will be compared.

Specific Aim 2: To assess the effects of successful periodontal therapy on the level of glycemic control in this Gullah African American population. Authors addressing whether the treatment of periodontitis or other infections of the oral cavity can improve glycemic control in diabetic patients report contradictory results. We will treat periodontal patients with mechanical therapy (scaling and root planning) and oral hygiene instruction, with or without systemic antibiotic administration (Table 1). The HbA1c, fasting glucose and clinical periodontal parameters will be evaluated prior to the periodontal intervention, and at 3 and 6 months after therapy. We plan to continue to recruit, enroll and assess new patients from the Gullah African American community living on the Sea Islands of the South Carolina coast for future research projects

Specific Aim 3: To assess the concentration of the catalytically active form of MMP-8 at baseline (prior to periodontal intervention) and at 3 and 6 months later. Polymorphonuclear (PMN) leukocyte-derived MMP-8 is predominantly present in periodontitis-affected GCF9,15-16. Analysis of GCF for aMMP-8 could provide a novel useful noninvasive technique to assess and monitor the pathophysiological status of the periodontium tissue in a site-specific manner9-10.

Conditions

Periodontal Disease; Type 2 Diabetes Mellitus

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

Control

Participants received mechanical periodontal therapy, oral hygiene instructions and placebo (antibiotic) pills.

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Participants received mechanical periodontal therapy, oral hygiene instructions and placebo pills.

Doxycycline

Participants received mechanical periodontal therapy, oral hygiene instructions and antibiotic (Doxycycline 100mg x 14 pills)

Group Type: EXPERIMENTAL

Doxycycline

Intervention Type: DRUG

Participants received mechanical periodontal therapy, oral hygiene instructions and Doxycycline 100mg x 14 pills (to be taken one a day for 14 days)

Interventions

Placebo

Participants received mechanical periodontal therapy, oral hygiene instructions and placebo pills.

Intervention Type: DRUG

Doxycycline

Participants received mechanical periodontal therapy, oral hygiene instructions and Doxycycline 100mg x 14 pills (to be taken one a day for 14 days)

Intervention Type: DRUG

Other Intervention Names

Control Group; Intervention Group

Eligibility Criteria

Inclusion Criteria

• Gullah African Americans;
• With type 2 diabetes mellitus defined according to the American Diabetes Association criteria;

• AIM 1: Participants who have received oral, dental, periodontal, diabetes and genotype assessment through enrollment in Dr. J. Fernandes' COBRE project.
• AIM 2 and 3: Participants with severe chronic periodontitis, as defined by at least one tooth surface with probing depth (PD)≥5mm.

Exclusion Criteria

• Severe concurrent illnesses / conditions that would limit their daily life or require extensive systemic treatment, such as malignancy, severe cardiovascular disease, organ transplant, or inadequate understanding due to mental disorders;
• Finger stick blood glucose measurement of more than 350mg/dl or less than 70mg/dl after second measurement;
• Systolic blood pressure of more than 180mm Hg or diastolic pressure of more than 100mm Hg;
• Fasting serum C-peptide < 1ng/ml (documentation or test);
• Serum creatinine ≥ 1.6mg/dl;
• Abnormal hepatic function;
• Hemoglobinopathy (sickle cell trait/hemolytic anemia) interfering with HbA1c monitoring;
• Other underlying illness/conditions which, in the doctor's judgment, may prevent patient from adherence to the study protocol;
• Unwillingness to sign the informed consent form or enter the study;
• Pregnant women;
• Patients in need of antibiotic prophylaxis prior to dental procedures or patients that have been treated with any kind of antibiotics in the past 3 months.

• Minimum Eligible Age: 13 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Center for Research Resources (NCRR)

NIH

Sponsor Role: collaborator

Medical University of South Carolina

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Renata S. Leite

Role: STUDY_DIRECTOR

Medical University of South Carolina

Other Identifiers

P20RR017696

Identifier Type: NIH

Identifier Source: secondary_id

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P20RR017696-06

Identifier Type: NIH

Identifier Source: org_study_id

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