Stress Reactivity of Physical Stressor on Depression

NCT ID: NCT01791023

Last Updated: 2013-02-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 80 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-03-31
• Study Completion Date: 2012-12-31

Brief Summary

Depressive elderly individuals have showed higher basal level of cortisol and lower level of dehydroepiandrosterone (DHEA). Moreover, changes on these hormone levels have also observed in reactivity of an acute stress, such as physical exercise. On the other hand, physical training can modulate the release of these hormones. Therefore, depressive elderly individuals physically actives might show attenuated reactivity of an acute physical stressor compared to sedentary elderly individuals. The aim of these study is to compare the effect of an acute physical stressor on cortisol levels in depressive and healthy individuals, physically actives and sedentaries. Additionally, the sulfated form of DHEA (DHEAS) serves as a reservoir for DHEA, because of that it is expected that DHEAS levels might reduce after the acute physical exercise.

Detailed Description

Depressive and healthy individuals were submitted to one session of 30 minutes of physical exercise of moderate intensity. Before and soon after the exercise it was collected saliva - to analyse cortisol and DHEAS hormones - and some psychological and physical aspects were also collected, such as anamneses, scales of anxiety, temperaments, mood, stress and quality of life. Moreover, during exercise heart rate and mood scale were assessed. To evaluate the reactivity and recovery of physical stressor (physical exercise) saliva tubes and psychological scales were collected 30 minutes and 45 minutes after the end of exercise.

Conditions

Depression

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Physical exercise

Physical exercise

Group Type: EXPERIMENTAL

Physical exercise

Intervention Type: OTHER

30 minutes of aerobic exercise on treadmill with moderate intensity.

Interventions

Physical exercise

30 minutes of aerobic exercise on treadmill with moderate intensity.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Age above of 60 years old
• Clinical diagnostic of depression

Exclusion Criteria

• Hormonal replacement
• Physical disease
• Fasting

• Minimum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Universidade Federal do Rio de Janeiro

OTHER

Sponsor Role: lead

Responsible Party

Helena Sales de Moraes

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Helena S Moraes, Ms

Role: PRINCIPAL_INVESTIGATOR

Universidade Federal do Rio de Janeiro

Locations

Deolindo Couto Neurology Institute

Rio de Janeiro, Rio de Janeiro, Brazil

Countries

Brazil

Other Identifiers

cortisolexercise01

Identifier Type: -

Identifier Source: org_study_id