Carbon Monoxide Blood and DNA Biorepository

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-02-29

Study Completion Date

2032-12-31

Brief Summary

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The purpose of this biorepository is to collect blood from patients at the time of CO poisoning and at follow-up visits months to years later. These samples can be used in the future to learn more about how CO damages the heart and brain and whether blood tests could predict which patients will have problems after CO poisoning.

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Detailed Description

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The investigators propose to establish a biorepository for storage of serum, plasma, and DNA collected from patients with carbon monoxide (CO) poisoning. Participants will also be evaluated for clinical outcome. The biorepository will include serum and plasma from CO-poisoned patients drawn at the time of injury as well as from blood drawn at clinical follow-up visits. The biorepository will also bank DNA from these participants.

These specimens can be analyzed in the future to elucidate potential inflammatory and immunological mechanisms that cause brain and heart damage and identify possible biological and genetic predictors of poor outcome.

Conditions

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Carbon Monoxide Poisoning

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Biorepository

Patients with acute CO poisoning. Blood collection for biorepository only, no study intervention.

No study intervention

Intervention Type OTHER

There is no study-related intervention.

Interventions

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No study intervention

There is no study-related intervention.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Symptomatic carbon monoxide poisoning (headache, nausea, vomiting, dizziness, fatigue, muscle aches, slowed mentation, confusion, loss of consciousness, etc.).
2. Documented exposure to carbon monoxide and no other reasonable explanation for their signs and symptoms.

Exclusion Criteria

1. Pregnancy
2. Age \< 18 years
3. Unable to obtain informed consent
5. Anemia requiring blood products within the last 4 months or hematocrit less than the laboratory normal reference range

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No