Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

54 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-10-01

Study Completion Date

2026-07-31

Brief Summary

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Mitochondria are structures inside cells that are responsible for producing energy from nutrients through a series of steps, using oxygen. To have an idea of how well the mitochondria can produce energy, we can measure how much oxygen they use. The goal of this study is to:

1. To compare the oxygen use between people with long COVID and people who completely recovered after COVID-19, using three techniques that measure the oxygen use in blood cells, on the skin and in the muscle
2. To test how similar these three techniques are in measuring the oxygen used in the three different tissues

Participants will:

* Complete surveys,
* Wear an activity tracker (7 days),
* Undergo several non-invasive tests, and
* Donate a blood sample The study will take place in UZ Brussel hospital and will take 2 study visits, approximately 7 days apart.

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Detailed Description

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Conditions

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Long COVID Post-COVID-19 Condition

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Individuals with long COVID

History of a confirmed or documented SARS-CoV-2 infection and long COVID according to the World Health Organisation's clinical case definition

No interventions assigned to this group

Convalescent individuals

History of a confirmed or documented SARS-CoV-2 infection, complete recovery after the SARS-CoV-2 infection, no history of long COVID according to the World Health Organisation's clinical case definition

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Long COVID diagnosis, based on the WHO definition;
* Presence of long COVID symptoms for a minimum of 6 months.
* History of confirmed or documented SARS-CoV-2 infection.
* Adult (≥18 years of age).
* Post-COVID-19 Functional Status Scale grade 2-4, while they had a grade 0 before the SARS-CoV-2 infection.

* History of confirmed or documented SARS-CoV-2 infection.
* Complete recovery after the SARS-CoV-2 infection, no history of long COVID based on the WHO definition;
* Post-COVID-19 Functional Status Scale \[2\] grade 0 both before the infection and currently.
* Adult (≥18 years of age).

Exclusion Criteria

* Pre-existing chronic diseases potentially affecting the functional status scale.
* Treatment with metabolism altering drugs.
* \> 10 standard units of alcohol (10 grams of alcohol/glass) per week.
* Unable to understand oral and written instructions in Dutch, French or English.
* Allergies to medical adhesive bandages.
* Porphyria and other skin conditions aggravated by sunlight.

Convalescent individuals

* Pre-existing chronic non-communicable diseases (e.g. hypertension, chronic respiratory diseases, diabetes).
* Treatment with metabolism altering drugs.
* \> 10 standard units of alcohol (10 grams of alcohol/glass) per week.
* Unable to understand oral and written instructions in Dutch, French or English.
* Allergies to medical adhesive bandages.
* Porphyria and other skin conditions aggravated by sunlight.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Elisabeth De Waele

Head of the Department of Clinical Nutrition, Co-director of Vitality Research Group

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Elisabeth De Waele, MD. PhD.

Role: PRINCIPAL_INVESTIGATOR

Vitality Research Group, Metabolism and Nutrition, Vrije Universiteit Brussel (VUB), Clinical Nutrition Department, Universitair Ziekenhuis Brussel (UZ Brussel)