T-Cell Mitochondrial Respiration Response to Ketone Monoester Supplement in Healthy Volunteers and COVID-19
NCT ID: NCT05798260
Last Updated: 2024-06-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
OBSERVATIONAL
2024-06-30
2024-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Healthy Volunteers
Healthy Volunteers
Agilent Seahorse XF Cell Mito Stress Test
The Agilent Seahorse XF Cell Mito Stress Test measures key parameters of mitochondrial function by directly measuring the oxygen consumption rate (OCR) of cells on the Seahorse XFe and XF Extracellular Flux Analyzers. It is a plate-based live cell assay that allows to monitor spare respiratory capacity (SRC), basal respiration, ATP production-coupled respiration, maximal respiration, and non-mitochondrial respiration in real time before and after ketone monoester
COVID-19 positive admitted to the ICU and on the ventilator
COVID-19 positive admitted to the ICU and on the ventilator
Agilent Seahorse XF Cell Mito Stress Test
The Agilent Seahorse XF Cell Mito Stress Test measures key parameters of mitochondrial function by directly measuring the oxygen consumption rate (OCR) of cells on the Seahorse XFe and XF Extracellular Flux Analyzers. It is a plate-based live cell assay that allows to monitor spare respiratory capacity (SRC), basal respiration, ATP production-coupled respiration, maximal respiration, and non-mitochondrial respiration in real time before and after ketone monoester
Interventions
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Agilent Seahorse XF Cell Mito Stress Test
The Agilent Seahorse XF Cell Mito Stress Test measures key parameters of mitochondrial function by directly measuring the oxygen consumption rate (OCR) of cells on the Seahorse XFe and XF Extracellular Flux Analyzers. It is a plate-based live cell assay that allows to monitor spare respiratory capacity (SRC), basal respiration, ATP production-coupled respiration, maximal respiration, and non-mitochondrial respiration in real time before and after ketone monoester
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* \<18 years
* Steroid use
18 Years
ALL
Yes
Sponsors
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Duke University
OTHER
Responsible Party
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Principal Investigators
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Christina Barkauskas, MD
Role: PRINCIPAL_INVESTIGATOR
Research Director Duke Medical ICU
Locations
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Christina Barkauskas
Durham, North Carolina, United States
Countries
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Other Identifiers
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Pro00101196
Identifier Type: -
Identifier Source: org_study_id
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