Survivorship of Attune Primary Total Knee Prosthesis

NCT ID: NCT01754363

Last Updated: 2026-01-16

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 1542 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-02-01
• Study Completion Date: 2030-02-01

Brief Summary

This post-marketing investigation will evaluate the long term (up to 15 years) survivorship of the Attune Primary Knee Prosthesis in patients with non-inflammatory degenerative joint disease. Data from Subjects who receive one of four knee configurations will be pooled to establish a contemporary dataset.

Detailed Description

Approximately 30 sites, worldwide, will recruit 1200 patients (1200 knees). Each study site is expected to enroll approximately 50 patients (50 knees). An additional 10 subjects per site may be recruited at sites which have Sub-Investigators participating in the study. Cohort reallocation is permitted. There is no control group. One thousand two hundred (1200) Subjects will be stratified into 4 subgroups of 300: cruciate retaining fixed bearing(CR FB), cruciate retaining rotating platform (CR RP), posterior stabilized fixed bearing (PS FB), and posterior stabilized rotating platform (PS RP).

Treatment assignment in this study is not randomized. Each site will only enroll patients in one of the four knee configuration sub-groups most commonly used as their standard of care.

This study allowed for enrolment into the study by two methods. The first method was by enroling subjects to receive the implant under study with the expectation to follow them out to 15 years. The second method was done to offset follow-up attrition. The second method allowed additional interested sites that had previously participated in a two-year follow-up study (NCT01746524) on this implant (subjects implanted and followed for two years) to reconsent interested subjects to be further followed out to 15 years in this study. The original 29 sites enroled 1232 subjects. Adding of the interested sites from the 2-yr follow-up study (NCT01746524) increased the sites from 29 to 37 sites. As of the last study update, the current enrolment is now1538.

Conditions

Noninflammatory Degenerative Joint Disease

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Attune Primary Total Knee Replacement

Subjects will receive one of the following Attune total knee implants:

Cruciate retaining fixed bearing (CR FB) Cruciate retaining rotating platform (CR RP) Posterior stabilized fixed bearing (PS FB) Posterior stabilized rotating platform (PS RP)

Group Type: EXPERIMENTAL

Attune Primary Total Knee Replacement

Intervention Type: DEVICE

Patients will undergo a primary total knee replacement using one of the four configurations of the Attune knee (CR FB, CR RP, PS FB, PS RP).

Interventions

Attune Primary Total Knee Replacement

Patients will undergo a primary total knee replacement using one of the four configurations of the Attune knee (CR FB, CR RP, PS FB, PS RP).

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Subject is male or female and between the ages of 22 and 75 years at the time of surgery, inclusive.
• Subject was diagnosed with NIDJD.
• Subject is a suitable candidate for cemented primary total knee arthroplasty using the devices described in this protocol with either resurfaced or non-resurfaced patellae.
• Subject has given voluntary, written informed consent to participate in this clinical investigation and has authorized the transfer of his/her information to DePuy.
• Subject is currently not bedridden.
• Subject in the opinion of the Clinical Investigator, is able to understand this clinical investigation and is willing and able to perform all study procedure and follow-up visits and co-operate with investigational procedures.
• Subject must be comfortable with speaking, reading and understanding questions and providing responses in an available translated language for the PROs in the protocol.
• The devices specified in this protocol were implanted.

Exclusion Criteria

• Subject is a woman who is pregnant or lactating.
• Contralateral knee has already been enrolled in this study.
• Subject had a contralateral amputation.
• Previous partial knee replacement (unilateral, bicompartmental or patellofemoral joint replacement), patellectomy, high tibial osteotomy or primary TKA in affected knee.
• Subject is currently experiencing radicular pain from the spine.
• Subject has participated in an IDE/IND clinical investigation with an investigational product in the last three months.
• Subject is currently involved in any personal injury litigation, medical-legal or worker's compensation claims.
• Subject is a known drug or alcohol abuser or has a psychological disorder that could affect their ability to complete patient reported questionnaires.
• Subject was diagnosed with fibromyalgia that is currently being treated with prescription medication.
• Subject has significant neurological or musculoskeletal disorders or disease that may adversely affect gait or weight bearing (e.g. muscular dystrophy, multiple sclerosis, Charcot disease).
• Subject is suffering from inflammatory arthritis (e.g. rheumatoid arthritis, juvenile rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosis, etc.).
• Subject is not comfortable with speaking, reading, and understanding questions and providing responses in an available translated language for the PROs in the protocol.
• Subject has a medical condition with less than 5 years of life expectancy.

• Minimum Eligible Age: 22 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

DePuy International

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Allyson Morris

Role: STUDY_DIRECTOR

DePuy Synthes

Locations

Mayo Clinic Arizona

Scottsdale, Arizona, United States

Orthopaedic Specialty Institute

Orange, California, United States

Florida Research Associates, LLC

DeLand, Florida, United States

Center for Hip and Knee Surgery

Mooresville, Indiana, United States

University of Iowa Hospitals & Clinics

Iowa City, Iowa, United States

Washington University School of Medicine

St Louis, Missouri, United States

Orthopedic One

Columbus, Ohio, United States

OrthoNeuro

New Albany, Ohio, United States

Penn State Hershey Bone & Joint Institute

Hershey, Pennsylvania, United States

Texas Institute for Hip and Knee Surgery, LLC

Austin, Texas, United States

Canberra Hospital-Trauma & Orthopaedic Research Unit

Adelaide, South Australia, Australia

Univ.-Klinik für Orthopädie

Vienna, Lower Austria, Austria

Krankenhaus der Barmherzigen

Linz, Upper Austria, Austria

Monica Camputs O.L.V. Middelares

Antwerp, , Belgium

University of Western Ontario-Department of Orthopaedic Surgery

London, Ontario, Canada

Orthopädische Klinik für die Universität Regensburg

Bad Abbach, Bavaria, Germany

UniversitatsKlinikum Heidelberg

Heidelberg, , Germany

Queen Mary Hospital

Hong Kong, , Hong Kong

University Malaya Medical Centre

Kuala Lumpur, , Malaysia

Ascot Hospital

Auckland, , New Zealand

Singapore General Hospital-Dept of Orthopaedic Surgery

Singapore, , Singapore

Seoul National University Boramae Hospital

Seoul, Dongjak-gu, South Korea

Seoul National University Hospital

Seoul, , South Korea

Queen Mary Hospital

Dunfermline, Fife, United Kingdom

Robert Jones & Agnes Hunt Orthopaedic Hospital

Gobowen, Oswestry, United Kingdom

New Royal Infirmary of Edinburgh

Edinburgh, Scotland, United Kingdom

Princess Alexandria Hospital

Harlow, , United Kingdom

Clifton Park NHS Treatment Centre

York, , United Kingdom

Countries

United States; Australia; Austria; Belgium; Canada; Germany; Hong Kong; Malaysia; New Zealand; Singapore; South Korea; United Kingdom

Other Identifiers

10008

Identifier Type: -

Identifier Source: org_study_id