Dietary Fiber for Fecal Incontinence

NCT ID: NCT01738607

Last Updated: 2023-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

206 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-04-30

Study Completion Date

2010-12-31

Brief Summary

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The primary aim of this study was to compare the effects of supplementation with one of three dietary fibers (gum arabic, carboxy-methylcellulose, or psyllium) or a placebo on fecal incontinence (FI), symptom intolerance, and quality of life in community-living individuals who have incontinence of loose or liquid feces. A secondary aim was to explore the possible mechanism(s) underlying the supplements' efficacy (i.e., improvements in stool consistency, water-holding capacity or gel formation).

Detailed Description

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Conditions

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Fecal Incontinence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Placebo

basic recipe for juice and muffin recipe

abbreviated PLB

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Carboxymethylcellulose

The supplements were prepared as two fruit juice mixtures (each 270 ml) providing 7 g total fiber/d) and two small muffins providing 9 g total fiber/d for 16 g of toal fiber daily.

abbreviated CMC

Group Type EXPERIMENTAL

carboxymethylcellulose

Intervention Type DIETARY_SUPPLEMENT

dietary fiber

Gum Arabic

The supplements were prepared as two fruit juice mixtures (each 270 ml) providing 7 g total fiber/d) and two small muffins providing 9 g total fiber/d for 16 g of toal fiber daily.

abbreviated GA

Group Type EXPERIMENTAL

Gum Arabic

Intervention Type DIETARY_SUPPLEMENT

Gum acacia dietary fiber

Psyllium

The supplements were prepared as two fruit juice mixtures (each 270 ml) providing 7 g total fiber/d) and two small muffins providing 9 g total fiber/d for 16 g of toal fiber daily.

abbreviated as PSY

Group Type EXPERIMENTAL

Psyllium

Intervention Type DIETARY_SUPPLEMENT

Interventions

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Psyllium

Intervention Type DIETARY_SUPPLEMENT

Gum Arabic

Gum acacia dietary fiber

Intervention Type DIETARY_SUPPLEMENT

carboxymethylcellulose

dietary fiber

Intervention Type DIETARY_SUPPLEMENT

Placebo

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Gum acacia

Eligibility Criteria

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Inclusion Criteria

* age ≥18 years
* living in the community (not a nursing home or assisted living facility)
* self-report of usually having FI of loose or liquid consistency at least twice in a 2-wk period
* toilets independently
* ability to read and write in English.
* Persons that regularly performed pelvic floor muscle exercises and/or biofeedback on a maintenance regimen for at least 20 wks or who took a steady dose of anti-motility medications on a regular schedule that still met the FI criteria were also eligible.

Exclusion Criteria

* difficulty swallowing,
* a gastrointestinal (GI) tract altered by surgery,
* a malabsorption disorder,
* inflammatory bowel disease,
* gastrointestinal cancer or active cancer treatment,
* allergy to the fibers,
* regularly used a laxative or enema, were tube-fed, or unwilling to discontinue taking periodic self-prescribed fiber supplements or anti-diarrheal medications.
* a score ≤24 on the Mini Mental State Examination
* having/reporting fewer than two episodes of FI or being incapable of performing study procedures during the run-in baseline period
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Minnesota

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Donna Z Bliss, phD

Role: PRINCIPAL_INVESTIGATOR

University of Minnesota

Locations

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University of Minnesota

Minneapolis, Minnesota, United States

Site Status

Countries

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United States

Other Identifiers

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R01NR007756-01A2

Identifier Type: NIH

Identifier Source: secondary_id

View Link

010M69241

Identifier Type: -

Identifier Source: org_study_id

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