Influence of CPB and Mini CPB to the Absorption of the Metoprolol

NCT ID: NCT01728272

Last Updated: 2015-08-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-11-30

Study Completion Date

2015-12-31

Brief Summary

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Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Detailed Description

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Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Blood samples for concentration of metoprolol are taken preoperaively, 1. and 3. day after operation, before and 10 times after intake of 50 mg metoprolol.

Sudy is randomized into 3 groups: 1. Miniperfusion n.15 2. Perfusion n.15 3. offpump n.15

Conditions

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Drug Absorption

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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blood concentration of metoprolol

how does off-pump miniperfusion and perfusion CABG influence the absorption of metoprolol after CABG

Group Type EXPERIMENTAL

blood concentration of metoprolol

Intervention Type DRUG

measure blood concentration of metoprolol

Interventions

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blood concentration of metoprolol

measure blood concentration of metoprolol

Intervention Type DRUG

Eligibility Criteria

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Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Kuopio University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Kuopio University Hospital

Kuopio, Kuopio, Finland

Site Status RECRUITING

Countries

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Finland

Facility Contacts

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Martin Maaroos, MD

Role: primary

358400218801

Other Identifiers

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KUH5101066

Identifier Type: -

Identifier Source: org_study_id

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