Safety and Efficacy Study of the Cardiapex Percutaneous Trans-apical Access and Closure System

NCT ID: NCT01722591

Last Updated: 2015-02-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Brief Summary

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A prospective, multicenter, uncontrolled study to evaluate the safety and efficacy of the Cardiapex percutaneous trans-apical access and closure system. The Cardiapex device intended for percutaneous access and closure of the left ventricular apex in conjunction with transapical Transcatheter Aortic Valve Implantation (TAVI).

Detailed Description

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Conditions

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Transapical Transcatheter Aortic Valve Implantation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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Cardiapex device

Use of the Cardiapex device in the context of transapical TAVI procedures

Group Type EXPERIMENTAL

Cardiapex device

Intervention Type DEVICE

Cardiapex percutaneous transapical access and closure system

Interventions

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Cardiapex device

Cardiapex percutaneous transapical access and closure system

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient scheduled for transapical TAVI
* Patient ≥ 70 years of age
* Patient able to give informed written consent
* Patient able to attend follow up examinations

Exclusion Criteria

* Scheduled concomitant non-TAVI cardiac procedure
* Patient with Left Ventricular Ejection Fraction (LVEF) \< 30% at time of enrollment
* Patient with known apical infarcted area
* Patient with a distinct large vessel right at the anatomical apex9 (based on pre-operative coronary angiography
* Patients with known lung tissue surrounding the apex and possibly interfering with the in-out puncture (based on preoperative gated CT assessment
* Patient with contra-indications to transapical TAVI
* Patient's inability to tolerate or comply with normal post-surgical drug regimen
* Patient's inability to comply with required follow-ups, including echocardiography
* Patient participation in other clinical trials within previous month
Minimum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cardiapex Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Kerckhoff Clinic

Bad Nauheim, , Germany

Site Status

Hamburg University Heart Center

Hamburg, , Germany

Site Status

Countries

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Germany

Other Identifiers

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CLN-PRO-01

Identifier Type: -

Identifier Source: org_study_id

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