Effects of Postoperative Residual Paralysis on Hospital Costs
NCT ID: NCT01718860
Last Updated: 2017-05-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
3000 participants
OBSERVATIONAL
2011-04-30
2017-12-31
Brief Summary
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Secondary analyses will be conducted to evaluate the effects of postoperative residual paralysis on potential cost-influencing factors, i.e. incidence of minor and major postoperative respiratory complications, hospital length of stay (LOS), unplanned intensive care unit (ICU) admission rate, as well as length of stay in the PACU.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Postoperative Residual Paralysis
Patients with train-of-four ratio less than 0.9 measured in the postanesthesia care unit
Quantitative measurement of neuromuscular transmission
Quantitative measurement of neuromuscular transmission with train-of-four watches.
No Postoperative Residual Paralysis
Patients with train-of-four ratio greater than 0.9 measured in the postanesthesia care unit
Quantitative measurement of neuromuscular transmission
Quantitative measurement of neuromuscular transmission with train-of-four watches.
Interventions
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Quantitative measurement of neuromuscular transmission
Quantitative measurement of neuromuscular transmission with train-of-four watches.
Eligibility Criteria
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Inclusion Criteria
* Each subject must be at least 18 years of age
* Train-of-four monitoring in the post-anesthesia care unit
Exclusion Criteria
* Children and pregnant women
18 Years
ALL
No
Sponsors
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Merck Sharp & Dohme LLC
INDUSTRY
Massachusetts General Hospital
OTHER
Responsible Party
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Matthias Eikermann
Dr.
Principal Investigators
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Matthias Eikermann, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Partners
Locations
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Massachusetts General Hospital
Boston, Massachusetts, United States
Countries
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References
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Butterly A, Bittner EA, George E, Sandberg WS, Eikermann M, Schmidt U. Postoperative residual curarization from intermediate-acting neuromuscular blocking agents delays recovery room discharge. Br J Anaesth. 2010 Sep;105(3):304-9. doi: 10.1093/bja/aeq157. Epub 2010 Jun 24.
Herbstreit F, Zigrahn D, Ochterbeck C, Peters J, Eikermann M. Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure. Anesthesiology. 2010 Dec;113(6):1280-8. doi: 10.1097/ALN.0b013e3181f70f3d.
Murphy GS, Szokol JW, Marymont JH, Greenberg SB, Avram MJ, Vender JS. Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit. Anesth Analg. 2008 Jul;107(1):130-7. doi: 10.1213/ane.0b013e31816d1268.
Berg H, Roed J, Viby-Mogensen J, Mortensen CR, Engbaek J, Skovgaard LT, Krintel JJ. Residual neuromuscular block is a risk factor for postoperative pulmonary complications. A prospective, randomised, and blinded study of postoperative pulmonary complications after atracurium, vecuronium and pancuronium. Acta Anaesthesiol Scand. 1997 Oct;41(9):1095-1103. doi: 10.1111/j.1399-6576.1997.tb04851.x.
Grosse-Sundrup M, Henneman JP, Sandberg WS, Bateman BT, Uribe JV, Nguyen NT, Ehrenfeld JM, Martinez EA, Kurth T, Eikermann M. Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study. BMJ. 2012 Oct 15;345:e6329. doi: 10.1136/bmj.e6329.
Sasaki N, Meyer MJ, Malviya SA, Stanislaus AB, MacDonald T, Doran ME, Igumenshcheva A, Hoang AH, Eikermann M. Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study. Anesthesiology. 2014 Nov;121(5):959-68. doi: 10.1097/ALN.0000000000000440.
Grabitz SD, Rajaratnam N, Chhagani K, Thevathasan T, Teja BJ, Deng H, Eikermann M, Kelly BJ. The Effects of Postoperative Residual Neuromuscular Blockade on Hospital Costs and Intensive Care Unit Admission: A Population-Based Cohort Study. Anesth Analg. 2019 Jun;128(6):1129-1136. doi: 10.1213/ANE.0000000000004028.
Other Identifiers
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IISP#39443
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
2016P002695
Identifier Type: -
Identifier Source: org_study_id
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