Role of the Renin Angiotensin Aldosterone System in the Mechanisms of Transition to Heart Failure in Abdominal Obesity
NCT ID: NCT01716819
Last Updated: 2015-08-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
101 participants
INTERVENTIONAL
2012-11-30
2015-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
NONE
Study Groups
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Abdominal obesity
Single arm, follow up cohort in patient with abdominal obesity. No comparator: description of interventions :
Composition of body mass by Dual x-ray absorptiometry Pulse wave velocity Electrocardiogram Urine sample Blood sample (and biological collection) Assessment of sleep apnea syndrome Glucose tolerance test Echocardiography Echotracking cardiac and abdominal magnetic resonance imaging Ambulatory blood pressure monitoring
Urine sample
dosages on one spot and 24h collection
Blood sample
dosages
Assessment of sleep apnea syndrome
Electrocardiogram
Glucose tolerance test
Echocardiography
cardiac and abdominal magnetic resonance imaging
Ambulatory blood pressure monitoring
Echotracking
Pulse wave velocity
Composition of body mass by Dual x-ray absorptiometry
Interventions
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Urine sample
dosages on one spot and 24h collection
Blood sample
dosages
Assessment of sleep apnea syndrome
Electrocardiogram
Glucose tolerance test
Echocardiography
cardiac and abdominal magnetic resonance imaging
Ambulatory blood pressure monitoring
Echotracking
Pulse wave velocity
Composition of body mass by Dual x-ray absorptiometry
Eligibility Criteria
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Inclusion Criteria
* Men and women aged between 40 and 65 year's old
* Caucasian
* Born or living in France for at least 10 years
* Presenting an abdominal obesity defined by a waist circumference \>94 cm in men and ≥ 80 cm in women, associated or not with untreated hypertension or hypertension treated for less than one year
* Having signed the informed consent
Exclusion Criteria
* Subjects unable to understand the information letter
* Subjects under supervision or guardianship
* pregnant or lactating woman
43 Years
72 Years
ALL
Yes
Sponsors
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Central Hospital, Nancy, France
OTHER
Responsible Party
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Principal Investigators
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Patrick ROSSIGNOL
Role: PRINCIPAL_INVESTIGATOR
CIC-P - INSERM - Institut Lorrain du Cœur et des vaisseaux Louis Mathieu
Locations
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CIC-P - INSERM - Institut Lorrain du Cœur et des vaisseaux
Vandœuvre-lès-Nancy, Meurthe et Moselle, France
Countries
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References
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Mandry D, Girerd N, Lamiral Z, Huttin O, Filippetti L, Micard E, Beaumont M, Ncho Mottoh MB, Pace N, Zannad F, Rossignol P, Marie PY. Relationship Between Left Ventricular Ejection Fraction Variation and Systemic Vascular Resistance: A Prospective Cardiovascular Magnetic Resonance Study. Front Cardiovasc Med. 2021 Dec 24;8:803567. doi: 10.3389/fcvm.2021.803567. eCollection 2021.
Other Identifiers
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2012-A00574-39
Identifier Type: -
Identifier Source: org_study_id
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