Early Diagnosis of Oral Cancer by Detecting p16 Methylation
NCT ID: NCT01695018
Last Updated: 2014-09-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
180 participants
OBSERVATIONAL
2009-02-28
Brief Summary
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Detailed Description
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Methods:180 patients with histologically confirmed mild or moderate OED were included in the present study. The investigators using p16 methylation diagnostic reagents to analysis of the p16 methylation status in these patients. Building two follow-up queue by p16-methylated and p16-unmethylated. The Statistical analysis used SAS6.12 software. All P-values were two-sided. P\<0.05 was considered to test for statistical significance difference.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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p16 methylation positive
48 patients with mild or moderate oral epithelial dysplasia containing methylated p16.
No interventions assigned to this group
p16 methylation negative
104 patients with p16 mild or moderate oral epithelial dysplasia NOT containing methylated p16.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* No local area stimulate by residual root and crown, sharp cusp, poor restoration and biting cheek or lips
* Without the OCE treatment history by laser , radiation or chemical
* Be able to Sign the informed consent
Exclusion Criteria
* Pregnancy or breast-feeding women
* Serious heart, lung, liver , kidney and other systemic diseases
* local area stimulate by residual root and crown, sharp cusp, poor restoration and biting cheek or lips
* OED treatment history by LASER, radiotherapy, or chemotherapy
* Tumor and psychiatric patients
* Patients are unable to cooperate
25 Years
78 Years
ALL
No
Sponsors
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Peking University
OTHER
Responsible Party
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Hongwei Liu, MD, PhD
Peking University School and Hospital of Stomatology
Principal Investigators
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Dajun Deng, MD
Role: PRINCIPAL_INVESTIGATOR
Peking University
Related Links
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Peking University
Other Identifiers
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PKUSSOM20120711
Identifier Type: -
Identifier Source: org_study_id
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