Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
35 participants
INTERVENTIONAL
2005-07-31
2006-06-30
Brief Summary
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* major polyphenolic constituent in green tea
* known as potent anti-carcinogenic, anti-inflammatory, anti-proliferative, and antimicrobial activities
* lipid-lowering and antiandrogenic properties was reported
* EGCG can improve acne vulgaris via one of the above mentioned actions.
Detailed Description
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In the recent decade, epigallocatechin-3-gallate (EGCG), the major polyphenolic constituent in green tea, has attracted much interest on account of its potent anti-carcinogenic, anti-inflammatory, anti-proliferative, and antimicrobial activities. Preclinical, observational, and clinical trial data have indicated that EGCG can inhibit tumor initiation, promotion, progression, and angiogenesis. EGCG also suppresses neutrophil chemotaxis, and has been suggested to improve many diseases that have inflammatory components such as diabetes, kidney injuries, arthritis, allergies, dental caries, cardiovascular, gastrointestinal, and neurodegenerative diseases. In skin, EGCG has been investigated mainly in light of antioxidative, immunopotentiating and anticarcinogenic properties against chemicals or ultraviolet irradiation. Moreover, EGCG has lipid-lowering and antiandrogenic properties, and can downregulate peroxisome proliferator-activated receptor-γ expression. Based on these observations, it can be inferred that EGCG might be effective in the treatment of acne.
Conditions
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Keywords
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Study Design
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RANDOMIZED
SINGLE_GROUP
TREATMENT
DOUBLE
Study Groups
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Topical EGCG 1%
Seventeen subjects were designated to use 1% EGCG .Since baseline visits, affected areas of randomly allocated half sides were treated with 1% solution twice daily, whereas those of the opposite sides were treated with vehicle only (3% ethanol).
topical EGCG application on acne
two times application of topical EGCG on acne lesion
topical EGCG 5%
Eighteen subjects were designated to use 5% EGCG, to evaluate a dose-response relationship. Since baseline visits, affected areas of randomly allocated half sides were treated with 5% EGCG solution twice daily, whereas those of the opposite sides were treated with vehicle only (3% ethanol).
topical EGCG application on acne
two times application of topical EGCG on acne lesion
Interventions
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topical EGCG application on acne
two times application of topical EGCG on acne lesion
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* clinical diagnosis of mild to moderate acne vulgaris
Exclusion Criteria
* any medical illness that might influence the results of the study,
* a previous history of oral acne medication or surgical procedures including laser treatment within 6 month and topical medication within 4 weeks of study enrollment.
15 Years
40 Years
ALL
No
Sponsors
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Seoul National University Hospital
OTHER
Responsible Party
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Dae Hun Suh
Professor
Principal Investigators
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Dae Hun Suh, M.D., Ph.D.
Role: STUDY_DIRECTOR
Department of Dermatology, Seoul National University College of Medicine
Locations
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Department of Dermatology, Seoul National University College of Medicine,
Seoul, , South Korea
Countries
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References
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Dominguez J, Hojyo MT, Celayo JL, Dominguez-Soto L, Teixeira F. Topical isotretinoin vs. topical retinoic acid in the treatment of acne vulgaris. Int J Dermatol. 1998 Jan;37(1):54-5. doi: 10.1046/j.1365-4362.1998.00254.x.
Abe I, Seki T, Umehara K, Miyase T, Noguchi H, Sakakibara J, Ono T. Green tea polyphenols: novel and potent inhibitors of squalene epoxidase. Biochem Biophys Res Commun. 2000 Feb 24;268(3):767-71. doi: 10.1006/bbrc.2000.2217.
Alexis AF, Jones VA, Stiller MJ. Potential therapeutic applications of tea in dermatology. Int J Dermatol. 1999 Oct;38(10):735-43. doi: 10.1046/j.1365-4362.1999.00796.x. No abstract available.
Other Identifiers
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04-2005-043-0
Identifier Type: -
Identifier Source: org_study_id