Safety and Bioavailability of Micellar Green Tea Extract

NCT ID: NCT06971536

Last Updated: 2025-05-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-10

Study Completion Date

2025-03-30

Brief Summary

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This study seeks to determine the short-term effects of daily oral supplementation of LipoMicel Green Tea on oral absorption and safety of green tea in healthy volunteers.

The primary objective is to evaluate and compare the pharmacokinetics of LipoMicel Green Tea (LGT) with that of a standard green tea extract formulation as well as a phytosomal green tea formulation. The secondary objective is to evaluate the safety of LGT in healthy human participants over a 30-day study period.

Detailed Description

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Conditions

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Bioavailability and Pharmacokinetics Safety

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Participants are randomly assigned to interventions in a crossover design to assess the pharmacokinetics over 48 hours; subsequently, the safety of LipoMicel Green tea intervention with the higher bioavailability is evaluated in a subsequent single-arm, 30-day trial.
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Standard Green Tea

Each participant receives their treatment i.e., Standard Green Tea hard gel capsules at a total dose of 300 mg green tea extract. Treatments are consumed with a glass of water (approx. 200mL), followed by a standardized breakfast (diet-controlled condition). Capillary whole blood samples are collected at different time points up to 48 hours post-dose. A washout period of at least 7 days between each treatment is used.

Group Type EXPERIMENTAL

Standard Green Tea

Intervention Type DIETARY_SUPPLEMENT

A maximum single dose of 300 mg green tea (hard gel capsules)

Phytosome Green Tea

Each participant receives their treatment i.e., Phytosome green tea hard gel capsules at a total dose of 250 mg green tea extract. Treatments are consumed with a glass of water (approx. 200mL), followed by a standardized breakfast (diet-controlled condition). Capillary whole blood samples are collected at different time points up to 48 hours post-dose. A washout period of at least 7 days between each treatment is used.

Group Type EXPERIMENTAL

Phytosome Green Tea

Intervention Type DIETARY_SUPPLEMENT

A maximum single dose of 250 mg green tea (hard gel capsules)

LipoMicel Green Tea

Each participant receives their treatment i.e., LipoMicel green tea soft gel capsules at a total dose of 300 mg green tea extract. Treatments are consumed with a glass of water (approx. 200mL), followed by a standardized breakfast (diet-controlled condition). Capillary whole blood samples are collected at different time points up to 48 hours post-dose. A washout period of at least 7 days between each treatment is used.

Group Type EXPERIMENTAL

LipoMicel Green Tea

Intervention Type DIETARY_SUPPLEMENT

A maximum single dose of 300 mg green tea (soft gel capsules)

Interventions

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Standard Green Tea

A maximum single dose of 300 mg green tea (hard gel capsules)

Intervention Type DIETARY_SUPPLEMENT

Phytosome Green Tea

A maximum single dose of 250 mg green tea (hard gel capsules)

Intervention Type DIETARY_SUPPLEMENT

LipoMicel Green Tea

A maximum single dose of 300 mg green tea (soft gel capsules)

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* male or female aged 21-65 years
* healthy, good physical condition
* voluntary, written, informed consent to participate in the study.

Exclusion Criteria

* use of anti-inflammatory or non-steroidal anti-inflammatory drugs
* previous history of cardiovascular disease or acute or chronic inflammatory disease
* use of antioxidant supplements or cholesterol-lowering agents
* change of diet habits or lifestyle (diet, physical activity, etc.)
* alcohol or substance abuse history
* use of nicotine or tobacco
* participation in another investigational study
Minimum Eligible Age

21 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Isura

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Julia Solnier

Role: PRINCIPAL_INVESTIGATOR

Isura

Locations

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ISURA

Burnaby, British Columbia, Canada

Site Status

Countries

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Canada

Other Identifiers

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2022-11-002GT

Identifier Type: -

Identifier Source: org_study_id

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