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Grass Sensitisation and Allergic Rhinitis in Thai Patients

NCT ID: NCT01686022

Last Updated: 2016-09-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2015-10-31

Brief Summary

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Allergic rhinitis patients are the patients who have nasal symptoms when triggered by indoor or outdoor allergens. Outdoor allergen can be divided into grass, tree, or weed. The type of grass or weed are different in various part of the world. The allergens from grass and weed has never been studied in Thailand. This study will find the major allergen from Bermuda grass, Johnson grass, Para grass, sedge, and ragweed, which are very common in Thailand. In addition, the investigators will study about the cross-reactivity among these group of allergen.

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Detailed Description

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To find the major allergen of grass and weed, the serum of patients will be used to bind with the allergen extract by immunoblot study.

The ELISA-inhibition will be used to study about cross-reactivity among various kinds of grass and weed.

Conditions

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Allergy to Grass Pollen Allergic Rhinitis Due to Weed Pollens

Study Groups

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Pollen Allergy

Pollen allergy and control will have the same intervention, ie. Skin prick test and collect serum samples.Then measure the specificIgE, immunoblot, and ELISA inhibition

Immunoblot

Intervention Type OTHER

serum specific IgE binds to grass extract by immunoblot

Interventions

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Immunoblot

serum specific IgE binds to grass extract by immunoblot

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Allergic rhinitis patients age 10-50 years old
* Control: healthy volunteer age 18-50 years old

Exclusion Criteria

* Chronic illness such as cardiovascular diseases, liver diseases
* History of anaphylaxis
* Pregnancy
Minimum Eligible Age

10 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Research Council of Thailand

OTHER_GOV

Sponsor Role collaborator

Mahidol University

OTHER

Sponsor Role lead

Responsible Party

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Punchama Pacharn

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Punchama Pacharn, MD

Role: PRINCIPAL_INVESTIGATOR

Mahidol University

Locations

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Siriraj Hospital

Bangkoknoi, Bangkok, Thailand

Site Status

Countries

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Thailand

Other Identifiers

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NRCT_G04

Identifier Type: -

Identifier Source: org_study_id

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