Validation of Receptor Occupancy Simulation

NCT ID: NCT01660880

Last Updated: 2019-04-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

7 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-12-31

Study Completion Date

2014-04-30

Brief Summary

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* To estimate dopamine receptor occupancy by aripiprazole using computer simulation
* To measure dopamine receptor occupancy by aripiprazole in patients treated with the antipsychotics
* To validate the simulation result by comparing the receptor occupancy from the simulation with that from the patients

Detailed Description

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Conditions

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Dopamine Receptor Occupancy Medication Satisfaction Prolactin Level Schizophrenia

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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aripiprazole

Patient group who is treated with aripiprazole

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* clinical diagnosis of schizophrenia
* treated with aripiprazole or risperidone
* no change in dose of antipsychotics for at least 6 weeks
* total PANSS score should be below 80

Exclusion Criteria

* Other psychiatric disorders rather than schizophrenia
* history of head trauma
* positive in urine hCG
* on antidepressant, anticholinergics or mood stabilizer
Minimum Eligible Age

20 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jun Soo Kwon

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jun Soo Kwon, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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A070001

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

C-1205-094-410

Identifier Type: -

Identifier Source: org_study_id

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