Change in Brain Metabolism and Cognitive Function by Aripiprazole

NCT ID: NCT01562808

Last Updated: 2012-03-26

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-01-31
• Study Completion Date: 2012-01-31

Brief Summary

Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task.

The investigators explored the relationship between changes in brain metabolism and working memory performance.

Conditions

Antipsychotics; Cognition; Brain Metabolism; Dopamine Receptor Occupancy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Interventions

Aripiprazole

single oral administration of aripiprazole

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• healthy volunteers
• right-handed

Exclusion Criteria

• any significant abnormality on routine lab
• any psychiatric disease

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Seoul National University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Jun Soo Kwon

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jun Soo Kwon, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

Seoul National University Hospital

Seoul, , South Korea

Countries

South Korea

Other Identifiers

A070001

Identifier Type: -

Identifier Source: org_study_id