A Study of Aripiprazole Lauroxil in Subjects With Schizophrenia or Schizoaffective Disorder

NCT ID: NCT02636842

Last Updated: 2016-07-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

47 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-12-31

Study Completion Date

2016-06-30

Brief Summary

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The study will determine the safety, tolerability, and pharmacokinetics of aripiprazole lauroxil in adults with schizophrenia or schizoaffective disorder.

Detailed Description

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Conditions

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Schizophrenia Schizoaffective Disorder

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Location

Deltoid or Gluteal Muscle

Group Type OTHER

Aripiprazole Lauroxil

Intervention Type DRUG

Intramuscular (IM) injection, single dose

Interventions

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Aripiprazole Lauroxil

Intramuscular (IM) injection, single dose

Intervention Type DRUG

Other Intervention Names

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ARISTADA TM

Eligibility Criteria

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Inclusion Criteria

* Has a diagnosis of chronic schizophrenia or schizoaffective disorder
* Has demonstrated ability to tolerate aripiprazole
* Has been on a stable antipsychotic medication regimen without any changes for at least 2 months prior to screening
* Has a body mass index (BMI) of 18.0 to 40.0 kg/m2, inclusive
* Additional criteria may apply

Exclusion Criteria

* Is pregnant, is planning to become pregnant, or is currently breastfeeding
* Has received aripiprazole lauroxil or IM depot aripiprazole within 6 months, or other long-acting, injectable antipsychotic medication within 3 months or currently treated with clozapine
* Is a danger to himself/herself at screening or upon admission
* Has a history of or positive test result for human immunodeficiency virus (HIV), hepatitis B, or hepatitis C
* Has a positive urine drug screen at screening or Day 1
* Additional criteria may apply
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alkermes, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robert Risinger, MD

Role: STUDY_DIRECTOR

Alkermes, Inc.

Locations

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Alkermes Investigational Site

Cerritos, California, United States

Site Status

Alkermes Investigational Site

Lemon Grove, California, United States

Site Status

Alkermes Investigational Site

Oakland, California, United States

Site Status

Alkermes Investigational Site

Hoffman Estates, Illinois, United States

Site Status

Alkermes Investigational Site

Marlton, New Jersey, United States

Site Status

Alkermes Investigative Site

Dallas, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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ALK9072-A106

Identifier Type: -

Identifier Source: org_study_id

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