A Study of Adjunctive Treatment of Aripiprazole in Schizophrenic Patients

NCT ID: NCT00300846

Last Updated: 2013-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-12-31

Study Completion Date

2007-07-31

Brief Summary

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The purpose of this study is to evaluate the effect on patient weight of adjunctive therapy of aripiprazole with clozapine versus clozapine monotherapy, in schizophrenic patients who are not optimally controlled on clozapine.

Detailed Description

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Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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A1

Group Type ACTIVE_COMPARATOR

aripiprazole

Intervention Type DRUG

Tablets, Oral, 5 mg, 10 mg, 15 mg, once daily, 16 weeks followed by 12 weeks of Open-Label extension phase (optional).

A2

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Tablets, Oral, 0 mg, once daily, 16 weeks followed by 12 weeks of Open-Label extension phase (optional)

Interventions

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aripiprazole

Tablets, Oral, 5 mg, 10 mg, 15 mg, once daily, 16 weeks followed by 12 weeks of Open-Label extension phase (optional).

Intervention Type DRUG

Placebo

Tablets, Oral, 0 mg, once daily, 16 weeks followed by 12 weeks of Open-Label extension phase (optional)

Intervention Type DRUG

Other Intervention Names

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Abilify

Eligibility Criteria

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Inclusion Criteria

* Patients with schizophrenia treated with clozapine (200-900 mg/day), who gained at least 2.5 kg while on clozapine.

Exclusion Criteria

* Patients known to be allergic to aripiprazole
* Hospitalized patients
* Patients who have previously received study medication in an aripiprazole clinical study or who have participated in any clinical trial with an investigational agent within the past month.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Otsuka America Pharmaceutical

INDUSTRY

Sponsor Role collaborator

Otsuka Pharmaceutical Development & Commercialization, Inc.

INDUSTRY

Sponsor Role lead

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution

Graz, , Austria

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Innsbruck, , Austria

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Vienna, , Austria

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Brno - Bohunice, , Czechia

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Hradec Králové, , Czechia

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Litoměřice, , Czechia

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Opava, , Czechia

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Prague, , Czechia

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Helsingin Kaupunki, , Finland

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Tampere, , Finland

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Turku, , Finland

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Brumath, , France

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Bully-les-Mines, , France

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Clermont-Ferrand, , France

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Limoges, , France

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Lyon, , France

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Nîmes, , France

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Paris, , France

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Rennex Cedex 7, , France

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Sotteville-lès-Rouen, , France

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Augsburg, , Germany

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Berlin, , Germany

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Duisburg, , Germany

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Haar, , Germany

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Heidelberg, , Germany

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Mannheim, , Germany

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Budapest, , Hungary

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Szolnok, , Hungary

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Krakow, , Poland

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Leszno, , Poland

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Skorzewo, , Poland

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Torun, , Poland

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Warsaw, , Poland

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Soweto, Gauteng, South Africa

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Vereeniging, Gauteng, South Africa

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Durban, KwaZulu-Natal, South Africa

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Bellville, Western Cape, South Africa

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Cape Town, Western Cape, South Africa

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Bromma, , Sweden

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Falköping, , Sweden

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Linköping, , Sweden

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Luleå, , Sweden

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Malmo, , Sweden

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Solna, , Sweden

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Uppsala, , Sweden

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Varberg, , Sweden

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Västra Frölunda, , Sweden

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Bern, , Switzerland

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Antalya, , Turkey (Türkiye)

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Istanbul, , Turkey (Türkiye)

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Izmir, , Turkey (Türkiye)

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Exeter, Devon, United Kingdom

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Teignmouth, Devon, United Kingdom

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Welwyn Garden City, Hertfordshire, United Kingdom

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Hull, North Yorkshire, United Kingdom

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Dundee, Tayside, United Kingdom

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London, , United Kingdom

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Countries

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Belgium Netherlands Spain Austria Czechia Finland France Germany Hungary Poland South Africa Sweden Switzerland Turkey (Türkiye) United Kingdom

References

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Fleischhacker WW, Heikkinen ME, Olie JP, Landsberg W, Dewaele P, McQuade RD, Loze JY, Hennicken D, Kerselaers W. Effects of adjunctive treatment with aripiprazole on body weight and clinical efficacy in schizophrenia patients treated with clozapine: a randomized, double-blind, placebo-controlled trial. Int J Neuropsychopharmacol. 2010 Sep;13(8):1115-25. doi: 10.1017/S1461145710000490. Epub 2010 May 12.

Reference Type DERIVED
PMID: 20459883 (View on PubMed)

Other Identifiers

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CN138-170

Identifier Type: -

Identifier Source: org_study_id