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Comorbidities and Healthcare Utilisation: Indicators for Improving COPD Diagnosis

NCT ID: NCT01655667

Last Updated: 2012-08-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

38859 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-12-31

Study Completion Date

2012-06-30

Brief Summary

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To characterise and understand the current UK COPD population including demographics, active comorbidities and missed opportunities for COPD diagnosis in the years previous to diagnosis

Detailed Description

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Using real-world primary care clinical databases, ascertain whether 1) trends in respiratory resource utilisation prior to COPD diagnosis (including lower respiratory tract infections \[LRTIs\], consultations and hospitalisations) could be used as 'flags' to aid earlier diagnosis, and 2) characterize comorbid conditions present at the time of COPD diagnosis, and evaluate the relationship to COPD disease severity and age at diagnosis.

Conditions

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Chronic Obstructive Pulmonary Disease

Keywords

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Diagnosis Primary Care Comorbidities Healthcare utilisation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Chronic Obstructive Pulmonary Disease

All patients with a coded diagnosis of COPD entered into their electronic clinical record between 1990 and 2009.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Aged 40 years or older
* Electronically coded diagnosis of COPD made between 1990 and 2009
* A minimum of three years continuous practice data including two years prior to and one year post diagnosis to ensure patients recieved COPD therapy post diagnosis
* Recieved two or more prescriptions for COPD therapies in the 12 months post diagnosis year 1.

Exclusion Criteria

* Aged less than 40 years
* No diagnosis of COPD between 1990 and 2009
* Less than three years continuous practice data including two years prior to and one year post diagnosis
* Less than two prescriptions for COPD therapies in the 12 months post diagnosis year 1.
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Department of Health, United Kingdom

OTHER_GOV

Sponsor Role collaborator

Research in Real-Life Ltd

NETWORK

Sponsor Role lead

Responsible Party

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Shuna Gould

Professor David Price

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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David B Price, MD

Role: PRINCIPAL_INVESTIGATOR

Research in Real-Life Ltd

Dermot Ryan, MBBS

Role: STUDY_DIRECTOR

University of Edinburgh

Rupert Jones, MBBS

Role: STUDY_DIRECTOR

Peninsula College of Medinicne and Dentistry

Eric Bateman, MD

Role: STUDY_DIRECTOR

University of Cape Town

Matt Kearney, MPH

Role: STUDY_DIRECTOR

Department of Health, United Kingdom

Locations

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Research in Real Life Ltd

Cambridge, Cambridgeshire, United Kingdom

Site Status

Countries

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United Kingdom

References

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Jones RC, Price D, Ryan D, Sims EJ, von Ziegenweidt J, Mascarenhas L, Burden A, Halpin DM, Winter R, Hill S, Kearney M, Holton K, Moger A, Freeman D, Chisholm A, Bateman ED; Respiratory Effectiveness Group. Opportunities to diagnose chronic obstructive pulmonary disease in routine care in the UK: a retrospective study of a clinical cohort. Lancet Respir Med. 2014 Apr;2(4):267-76. doi: 10.1016/S2213-2600(14)70008-6. Epub 2014 Feb 13.

Reference Type DERIVED
PMID: 24717623 (View on PubMed)

Other Identifiers

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015/11

Identifier Type: -

Identifier Source: org_study_id