Breath Analysis in Chronic Obstructive Lung Disease (COPD)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Study Completion Date

2017-11-30

Brief Summary

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To answer the question whether a disease specific profile of breath in patients with COPD can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

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Detailed Description

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This is an observational study comparing the volatile organic compounds (VOCs) in exhaled breath between COPD patients and matched control subjects (age, gender, smoking-state). 40 COPD patients (20 non-frequent, 20 frequent exacerbators) and 40 matched controls will be examined by SESI-MS on the composition of exhaled breath for identification of COPD specific markers.

Conditions

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COPD

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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COPD

40 COPD patients (20 non-frequent and 20 frequent-exacerbators). No intervention.

No interventions assigned to this group

Controls

Subjects with no apparent lung disease and normal lung function testing. Matched for age, gender and smoking history (pack years).

No intervention.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* confirmed COPD GOLD stage I-IV, based on a post-bronchodilator spirometry (FEV1/FVC \< 0.7) performed within the last 6 months
* age between 18 and 80 years at study entry
* healthy controls: normal spirometry

Exclusion Criteria

* COPD exacerbation within the last 6 weeks
* any lung disease other than COPD
* acute inflammatory disease (e.g. common cold) within the last 6 weeks
* acute or chronic hepatic disease
* renal failure or renal replacement therapy

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes