Assessing the Occupation Burden in COPD

NCT ID: NCT00006513

Last Updated: 2016-03-16

Basic Information

• Recruitment Status: COMPLETED
• Study Classification: OBSERVATIONAL
• Study Start Date: 2000-09-30
• Study Completion Date: 2004-08-31

Brief Summary

To assess the population burden of occupational exposures in the prevalence and progression of chronic obstructive pulmonary disease (COPD).

Detailed Description

BACKGROUND:

Chronic obstructive pulmonary disease is the only one of the top four or five leading causes of death in the U.S. with worsening epidemiological trends. Cigarette smoking accounts for approximately 85 percent-90 percent of cases, but the other 10 percent-15 percent of the attributable risk still represents a substantial fraction of this disease that remains unexplained. Recently, several studies, in various countries, have addressed whether certain occupational exposures (primarily those relating to dusts, vapors, gases, and/or fumes) are potential risk factors for COPD. Most of these studies have shown elevated odds ratios or relative risks, although not always to a statistically significant level.

DESIGN NARRATIVE:

A population sample of the continental United States of those aged 55-75, supplemented by an enriched sample in geographic "hot spots" identified by the National Institute for Occupational Safety and Health (NIOSH) through respiratory diseases mapping. Structured telephone interviews assessed demographics, health status, smoking exposures, and occupational histories. High risk jobs were coded using a job matrix system independent of subject report of specific exposures. Two hundred thirty-four of those with COPD, with over-sampling of those with greater severity, were followed at 12-14 months to assess health status and health services utilization, as well as decrements in quality of life.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Conditions

Lung Diseases, Obstructive; Chronic Obstructive Pulmonary Disease

Eligibility Criteria

Inclusion Criteria

No eligibility criteria

• Minimum Eligible Age: 55 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role: lead

Principal Investigators

Paul Blanc

Role:

University of California, San Francisco

References

Trupin L, Earnest G, San Pedro M, Balmes JR, Eisner MD, Yelin E, Katz PP, Blanc PD. The occupational burden of chronic obstructive pulmonary disease. Eur Respir J. 2003 Sep;22(3):462-9. doi: 10.1183/09031936.03.00094203.

Reference Type: BACKGROUND

PMID: 14516136 (View on PubMed)

Blanc PD, Eisner MD, Trupin L, Yelin EH, Katz PP, Balmes JR. The association between occupational factors and adverse health outcomes in chronic obstructive pulmonary disease. Occup Environ Med. 2004 Aug;61(8):661-7. doi: 10.1136/oem.2003.010058.

Reference Type: BACKGROUND

PMID: 15258271 (View on PubMed)

Other Identifiers

R01HL067438

Identifier Type: NIH

Identifier Source: secondary_id

View Link

949

Identifier Type: -

Identifier Source: org_study_id