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PET/CT in Psoriatic Arthritis

NCT ID: NCT01654198

Last Updated: 2020-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

12 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-07-31

Study Completion Date

2018-10-02

Brief Summary

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When patients with psoriasis develop joint pain, it is often hard to decide whether or not the pain is due to psoriatic arthritis (PsA). At this time, doctors use information from the history and physical exam to determine the diagnosis. X-rays, magnetic resonance imaging (MRI) and ultrasound have been used to help with the diagnosis but all three have limitations. A newer imaging technique, whole body Positron Emission Tomography/Computed Tomography (PET/CT) uses the idea that inflammatory cells take up sugar to locate inflammation in the body. Because patients with PsA have inflammatory cells in their joints and tendons, this type of scan allows the physician to take a picture of the whole body and locate inflammation. The investigators have found that some patients with psoriasis (but without arthritis) have inflammation in joints and tendons even before the patient has symptoms. In this study, the investigators will explore how well PET/CT works for assessing inflammation in patients with PsA. This would be a very exciting tool that could be used to find and treat inflammation before it causes damage or pain.

Detailed Description

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Conditions

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Psoriatic Arthritis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Psoriatic arthritis

FDG-PET/CT scan

Intervention Type RADIATION

FDG-PET/CT is a type of imaging used currently to look for cancer. We are using it to look at inflammation within the joints.

Interventions

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FDG-PET/CT scan

FDG-PET/CT is a type of imaging used currently to look for cancer. We are using it to look at inflammation within the joints.

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Age 18-80,
* active psoriatic arthritis (joint or enthesis inflammation)

Exclusion Criteria

* Diabetes,
* pregnant,
* no active PsA
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Pennsylvania

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alexis R Ogdie, MD, MSCE

Role: PRINCIPAL_INVESTIGATOR

University of Pennsylvania

Locations

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University of Pennsylvania Division of Rheumatology

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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815253

Identifier Type: -

Identifier Source: org_study_id