Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis

NCT ID: NCT02962271

Last Updated: 2016-11-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

187 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-31

Study Completion Date

2016-12-31

Brief Summary

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Psoriatic arthritis(PsA) and psoriasis(Ps) are two systemic inflammatory diseases linked with rash of psoriasis, but there's still great controversy regarding the exact relationship between them. Our study is to investigate the characteristics and differences of the ultrasonic imaging of enthesopathy in the lower extremity in patients with PsA and Ps, to explore the risk factors of Ps developing into PsA in the long term course.

Detailed Description

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As one of the most common chronic inflammatory skin diseases, psoriasis(Ps) can be intimately associated to psoriatic arthritis (PsA), affecting approximately 1% to 2% of the world's population. About 30% of them will develop into PsA with serious impact on their health-related quality of life.

PsA, characterised by different subsets with varying degree of severity, is a chronic, complicated inflammatory disease.Enthesitis is the prevalent and distinctive feature of PsA.

Musculoskeletal Ultrasound (MSUS) is a valid noninvasive modality, essential to evaluate entheses thickness, enthesophytes, bursitis and bone erosions as well as to disclose vascularisation on tendons through power doppler (PD) assessment. In recent years, more and more attention has been paid to the diagnosis and management of Ps and PsA, owing to its discrimination of identifying subclinical entheses and joint changes.

Conditions

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Enthesopathy

Keywords

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Musculoskeletal Ultrasound Psoriatic Arthritis Enthesopathy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Psoriatic Arthritis

Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed

Musculoskeletal Ultrasound

Intervention Type DEVICE

Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed

Psoriasis

Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed

Musculoskeletal Ultrasound

Intervention Type DEVICE

Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed

Interventions

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Musculoskeletal Ultrasound

Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, rheumatoid arthritis or osteoarthritis.
* Body Mass Index (BMI)\<30 kg/m2.
* Absence of local glucocorticoid or other drugs injection or surgical treatment for entheses scanned in the previous 6 weeks prior to clinical and musculoskeletal ultrasound (MSUS) evaluation.

Exclusion Criteria

* Other systemic rheumatic diseases or malignant neoplasms.
* Peripheral neuropathy of lower extremity.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chinese PLA General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jian Zhu

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jian Zhu

Role: PRINCIPAL_INVESTIGATOR

Department of Rheumatology,PLA General Hospital

Locations

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Chinese PLA General Hospital

Beijing, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Fei Sun

Role: CONTACT

Phone: 86-01-55499314

Email: [email protected]

Facility Contacts

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Feng Huang

Role: primary

Other Identifiers

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ChinaPLAGH-PsA

Identifier Type: -

Identifier Source: org_study_id