Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis
NCT ID: NCT00748254
Last Updated: 2026-01-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
113 participants
OBSERVATIONAL
2011-12-01
2027-01-31
Brief Summary
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Detailed Description
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Combining the advantages of both light and ultrasound scanning, PAT holds promise to present objective optical information in subsurface joint tissues with high sensitivity and high spatial resolution.
This could be of considerable help in the early detection of inflammatory joint diseases. PAT may also prove useful in further understanding the pathophysiology of these disorders and assisting with therapeutic decisions, including assessment of new pharmacological therapies.
In January 2026, the decision was made to reopen recruitment for this study to collect additional data to support future clinical trial work and funding.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Rheumatoid Arthritis
Patients who have active disease affecting the joints in the hand will have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound
Laser Based Photoacoustic Tomography, MRI, Ultrasound
Healthy subjects will have scans on finger joints with any of the scanning methods described above.
Normal controls
Healthy volunteers who do not have arthritis will also have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound on the joints of their hand
laser based photoacoustic tomography, MRI, ultrasound
Subjects with arthritis will have scans on finger joints with any of the scanning methods described above.
Interventions
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Laser Based Photoacoustic Tomography, MRI, Ultrasound
Healthy subjects will have scans on finger joints with any of the scanning methods described above.
laser based photoacoustic tomography, MRI, ultrasound
Subjects with arthritis will have scans on finger joints with any of the scanning methods described above.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patients can participate in this study if they have had rheumatoid arthritis for more than 2 years and their rheumatologist has referred them to this study.
* Patients can participate as a healthy volunteer with a known history of rheumatoid arthritis.
Exclusion Criteria
* Pregnant patients.
* Patients who is claustrophobic.
* Patients with impaired renal function cannot participate in this study such as elevate creatinine clearance, patients on kidney dialysis etc.
* Patients with shock hypotension or unstable low blood pressure.
* Patients with Rhabdomyolysis.
* Patients who have had a contrast enhanced (with gadolinium) MRA (magnetic resonance angiography)/ or MRI within the last 3 months. (Contrast is a medication injected into a vein during a imaging examination that helps produce clearer images/pictures).
18 Years
ALL
Yes
Sponsors
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National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
University of Michigan
OTHER
Responsible Party
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Xueding Wang
Principal Investigator
Principal Investigators
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Xueding Wang, Ph.D
Role: PRINCIPAL_INVESTIGATOR
University of Michigan
Locations
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Universtity of Michigan Health System
Ann Arbor, Michigan, United States
Countries
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Central Contacts
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Other Identifiers
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HUM00003693
Identifier Type: -
Identifier Source: org_study_id
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