Predicting Cognitive Resilience Against Sleep Loss

NCT ID: NCT01651429

Last Updated: 2014-06-16

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 48 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-04-30
• Study Completion Date: 2014-06-30

Brief Summary

Resilience is the ability to cope effectively and adapt to a wide range of stressful environmental challenges. Sleep loss has been shown to reduce activity in the brain regions responsible for resilience. The ability to resist the effects of sleep loss appears to be a stable, trait-like quality. This study will attempt to predict individuals' trait-resistance to sleep loss based on their neurobiology.

Detailed Description

Resilience, the ability to cope effectively and adapt to a wide range of stressful environmental challenges, appears to be mediated extensively by the medial prefrontal cortex (MPFC). Sleep deprivation has been shown to reduce metabolic activity throughout the brain, particularly the MPFC. The ability to resist the effects of sleep loss appears to be a stable, trait-like phenomenon that is consistent across situations, suggesting that it may reflect an enduring quality of the underlying neurobiological system. The present study aims to identify the neural basis of resilience and effectively discriminate resistant from vulnerable individuals during an overnight sleep deprivation session. Specifically, the primary aims of this research are 1) to further our understanding of the role of the MPFC in resilience and 2) to develop a statistical prediction algorithm based on multimodal neuroimaging that will reliably discriminate between individuals who are resilient versus vulnerable to the cognitive impairing effects of sleep loss.

Conditions

Sleep Deprivation

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: SCREENING
• Blinding Strategy: NONE

Study Groups

Sleep deprivation

Participants will undergo 29 hours of sleep deprivation, 17 of which will be spent in the laboratory.

Group Type: EXPERIMENTAL

Sleep deprivation

Intervention Type: BEHAVIORAL

Participants will undergo 29 hours of sleep deprivation. They will wake up at 7:00 am on the day of the study and remain awake in the laboratory until 12:00 pm the next day.

Interventions

Sleep deprivation

Participants will undergo 29 hours of sleep deprivation. They will wake up at 7:00 am on the day of the study and remain awake in the laboratory until 12:00 pm the next day.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Age 20-45 years
• Right handedness as assessed by the Edinburgh Handedness Inventory
• For women: regular menstrual cycles (duration between 25 and 35 days with no more than 3 day variation between cycle)

Exclusion Criteria

• History of head injury with loss of consciousness or post-traumatic amnesia, or major neurological illness
• Medical or neurologic condition that would confound interpretation of results, including alcohol or drug abuse/dependence in the past 6 months, neurological disorders including any history of seizures
• History of cardiac problems
• History of major depressive disorder or anxiety disorder
• Lifetime history of psychotic disorder, including bipolar disorder, schizophrenia, or obsessive compulsive disorder
• Other DSM-IV diagnosis that could affect interpretation of results
• Mixed or left handedness
• Abnormal visual acuity that cannot be corrected by contact lenses
• Daily caffeine use exceeding 400 mg per day
• History of smoking or tobacco use in the past year
• Metal within the body, pregnancy, or other contraindication for MRI procedures
• Use of drugs or medications that could affect functional neuroimaging results (e.g., fluoxetine, beta-blockers)
• Psychotropic medication use within the past 6 weeks

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Mclean Hospital

OTHER

Sponsor Role: lead

Responsible Party

William Killgore

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

William D Killgore, PhD

Role: PRINCIPAL_INVESTIGATOR

Mclean Hospital

Locations

McLean Hospital

Belmont, Massachusetts, United States

Countries

United States

Other Identifiers

D12AP00241

Identifier Type: -

Identifier Source: org_study_id