Helmet Ventilation in Acute Hypercapnic Respiratory Failure

NCT ID: NCT01645358

Last Updated: 2014-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-31

Study Completion Date

2014-09-30

Brief Summary

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Lack of tolerance to the treatment, makes the interface choice for non-invasive ventilation (NIV) one of the key factor. To date the helmet is rarely used in Acute Hypercapnic Respiratory Failure (AHRF), because of its large dead space, despite in hypoxic respiratory failure, it is largely employed as a "rotating" strategy when the facial mask is poorly tolerated.

In a multicenter randomized controlled trial, the investigators will compare the clinical efficacy of a new helmet designed to specifically improve the performance in chronic obstructive pulmonary disease (COPD) versus a full face mask during an episode of AHRF.

Detailed Description

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Conditions

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Hypercapnic Respiratory Failure Chronic Obstructive Pulmonary Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Helmet to deliver NIV

Group Type EXPERIMENTAL

Helmet (Starmed)

Intervention Type DEVICE

The helmet is a kind of interface similar to a hood to deliver NIV

Total Face to deliver NIV

Group Type ACTIVE_COMPARATOR

Total Face mask (Respironics)

Intervention Type DEVICE

The total face mask is the "classical" interface for NIV delivery

Interventions

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Helmet (Starmed)

The helmet is a kind of interface similar to a hood to deliver NIV

Intervention Type DEVICE

Total Face mask (Respironics)

The total face mask is the "classical" interface for NIV delivery

Intervention Type DEVICE

Other Intervention Names

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Starmed Helmet Respironics Performax or similar

Eligibility Criteria

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Inclusion Criteria

* pH \< 7,35 and PaCO2 \> 45 mmHg
* respiratory rate \> 20 b/min

Exclusion Criteria

* hypoxic respiratory failure
* coma
* inability to stand NIV
* lack of informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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IRCCS Azienda Ospedaliero-Universitaria di Bologna

OTHER

Sponsor Role lead

Responsible Party

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dr. Stefano Nava

Chief Respiratory and Critical care

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sant'Orsola malpighi Hospital

Bologna, , Italy

Site Status

Sant'Orsola Malpighi

Bologna, , Italy

Site Status

Countries

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Italy

References

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Pisani L, Mega C, Vaschetto R, Bellone A, Scala R, Cosentini R, Musti M, Del Forno M, Grassi M, Fasano L, Navalesi P, Nava S. Oronasal mask versus helmet in acute hypercapnic respiratory failure. Eur Respir J. 2015 Mar;45(3):691-9. doi: 10.1183/09031936.00053814. Epub 2014 Dec 10.

Reference Type DERIVED
PMID: 25504992 (View on PubMed)

Other Identifiers

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1222

Identifier Type: -

Identifier Source: org_study_id

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