PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata

NCT ID: NCT01642472

Last Updated: 2016-01-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-31

Study Completion Date

2015-04-30

Brief Summary

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This is a phase III, multicentre, long-term open-label extension of the phase III study: Pearl IIIextension (PGL09-027). During Pearl III (PGL09-026) and subsequent Pearl III extension (PGL09-027), patients have been exposed to a total of 4 cycles of daily 3month open-label treatment with ulipristal acetate 10mg before entering the proposed study Pearl extension 2 (PGL11-024).

This proposed study consists of 4 further consecutive courses of 3 months (84 days) open label ulipristal acetate 10mg once daily treatment each separated by a drug free period.

Detailed Description

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Conditions

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Uterine Fibroids

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Ulipristal Acetate (PGL4001) 10mg

Ulipristal Acetate (PGL4001)10mg daily administration

Group Type EXPERIMENTAL

Ulipristal Acetate - open label

Intervention Type DRUG

Ulipristal Acetate (PGL4001) tablets 10mg orally daily for 3 months (84 days) for each treatment course. There are four 3-month treatment courses in this study.

Interventions

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Ulipristal Acetate - open label

Ulipristal Acetate (PGL4001) tablets 10mg orally daily for 3 months (84 days) for each treatment course. There are four 3-month treatment courses in this study.

Intervention Type DRUG

Other Intervention Names

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PGL4001

Eligibility Criteria

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Inclusion Criteria

* Subject completed visit F - Follow-up of Pearl III extension study (PGL09-027) - without significant deviations.
* Females of childbearing potential are advised to practice a non-hormonal method of contraception.

Exclusion Criteria

* Subject has a history of uterus surgery (e.g. hysterectomy, myomectomy) or uterine artery embolization in Pearl III extension (PGL09-027) or afterwards that would interfere with the study assessments.
* Subject has taken or is likely to require treatment during the study with drugs that are not permitted by the study protocol.
* Subject is lactating, has a positive pregnancy test at study start or is planning a pregnancy during the course of the study.
* Subject has abnormal baseline findings, any other medical condition(s) or laboratory finding that, in the opinion of the investigator, might jeopardise the subject's safety or interfere with study evaluations.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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PregLem SA

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Elke Bestel, Dr

Role: STUDY_DIRECTOR

PregLem SA

Locations

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Medical University Vienna

Vienna, , Austria

Site Status

Cliniques Universitaires Saint-Luc, Gynécologie-Obstétrique,

Brussels, , Belgium

Site Status

CHR de la Citadelle

Liège, , Belgium

Site Status

Cliniques Universitaires UCL de Mont-Godinne

Yvoir, , Belgium

Site Status

Prywatna Klinika Polozniczo-Ginekologiczna

Bialystok, , Poland

Site Status

INVICTA Sp. Z o.o.

Gdansk, , Poland

Site Status

Private practice

Katowice, , Poland

Site Status

Prywatny Gabinet Lekarski Ginekologia I Poloznictwo Ultrasonografia

Lodz, , Poland

Site Status

Specjalistyczny Gabinet Ginekologiczno-Polozniczy

Lublin, , Poland

Site Status

Gabinet Lekarski Specjalistyczny "Sonus"

Warsaw, , Poland

Site Status

Centralny Szpital Kliniczny MSWiA w Warszawie, Klinika Poloznictwa, Chorob Kobiecych i Ginekologii Onkologicznej

Warsaw, , Poland

Site Status

Samodzielny Publiczny Szpital Kliniczny Nr 1 we Wrocławiu, I Katedra i Klinika Ginekologii i Położnictwa

Wroclaw, , Poland

Site Status

Hospital Universitario Vall Hebrón (Gynecology department) Edificio Maternal

Barcelona, , Spain

Site Status

Clinica Ginecologica CEOGA

Lugo, , Spain

Site Status

Private Practice

Madrid, , Spain

Site Status

HOSPITAL Universitario 12 de Octubre y Fundación de Investigación Biomédica Hospital 12 de Octubre

Madrid, , Spain

Site Status

Countries

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Austria Belgium Poland Spain

Other Identifiers

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PGL11-024

Identifier Type: -

Identifier Source: org_study_id

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