A Prospective Multicenter Non-interventional Study of Women Treated With ESMYA (Ulipristal Acetate) as Pre-operative Treatment of Moderate to Severe Symptoms of Uterine Fibroids

NCT ID: NCT01635452

Last Updated: 2015-01-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-05-31

Study Completion Date

2016-03-31

Brief Summary

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This is a multi-center, prospective, non-interventional study of patients who have been diagnosed with moderate to severe symptoms of uterine fibroids and are initiating a pre-operative treatment with ESMYA.

The objectives of the study are to characterize and describe treatment with ESMYA and to evaluate the safety, effectiveness, and HRQL outcomes in this population

Detailed Description

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Conditions

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Uterine Fibroids

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients treated with Esmya

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

\- Pre-menopausal adult women with a diagnosis of moderate or severe symptoms of uterine fibroids who are initiating treatment with ESMYA.

Exclusion Criteria

* Patient is pregnant or plans to become pregnant in the next 3 months,
* Patient is breastfeeding,
* Patient has genital bleeding of unknown etiology or not due to uterine fibroids,
* Patient has been diagnosed with uterine, cervical, ovarian or breast cancer,
* Patient is using an investigational drug/therapy or has discontinued the use of an investigational drug/therapy within 30 days prior to study enrollment,
* Patient has hypersensitivity to the active substance of ESMYA or to one of its excipients
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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PregLem SA

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jaime Oliver, MD

Role: STUDY_DIRECTOR

PregLem SA

Locations

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LKH Klagenfurt

Klagenfurt, , Austria

Site Status

Private practice

Sankt Pölten, , Austria

Site Status

CHU Pellegrin Gynécologie

Bordeaux, , France

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Hopital Bicetre

Le Kremlin-Bicètre, , France

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CHU La Conception

Marseille, , France

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CHU Hôpital Mère-enfant

Nantes, , France

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Tenon CHU Paris Est

Paris, , France

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CHUV Maison Blanche Institut

Reims, , France

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CHU Anne de Bretagne

Rennes, , France

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CHU Tours Gynécologie

Tours, , France

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Universitätsklinikum Aachen

Aachen, , Germany

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Klinik am Hofgarten

Bayreuth, , Germany

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Charite

Berlin, , Germany

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Private practice

Berlin, , Germany

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Medizinisches Zentrum Bonn Friedensplatz

Bonn, , Germany

Site Status

Private Practice

Bruchsal, , Germany

Site Status

Private practice

Cologne, , Germany

Site Status

Private Practice

Diepholz, , Germany

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Private practive

Dorsten, , Germany

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Private practice

Dortmund, , Germany

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Frauenklinik, Universitätsklinikum Erlangen

Erlangen, , Germany

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Klinikum Esslingen

Esslingen am Neckar, , Germany

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Universitäts Frauenklinik

Freiburg im Breisgau, , Germany

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Gynäkologische Praxis

Geseke, , Germany

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Hormonzentrum Altonaerstrasse

Hamburg, , Germany

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Gynaekologische Praxisklinik Harburger Ring

Harburg, , Germany

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Private practice

Hoyerswerda, , Germany

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Private practice

Ilsede, , Germany

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Private practice

Krefeld, , Germany

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Gynäkologische Praxis

Mainz, , Germany

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Endoskopie und Endometriose Zentrum

München, , Germany

Site Status

Klinikum der Universitaet Muenchen - Klinik und Poliklinik für Frauenheilkunde

München, , Germany

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Private practice

Rodgau, , Germany

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Fachaerzte fuer Frauenheilkunde und Geburtshilfe

Rotenburg (Wümme), , Germany

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Private practice

Völklingen, , Germany

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Semmelweis University Faculty of Medicine

Budapest, , Hungary

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University of Pécs Medical school

Pécs, , Hungary

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Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola-Malpighi

Bologna, , Italy

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Universita di Cagliari

Cagliari, , Italy

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Azienda Ospedaliera Garibaldi-Nesima

Catania, , Italy

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Azienda Ospedaliera-universitaria di Ferrar-Arcispedale Sant'Anna

Cona, , Italy

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Università degli Studi di Firenze

Florence, , Italy

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Clinica ospedale san martino e cliniche universitarie convenzionate di genova

Genova, , Italy

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IRCCS ospedale maggiore policlinico mangiagalli e regina elena di milano

Milan, , Italy

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La Sapienza University

Roma, , Italy

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Ospedale Mauriziano "Umberto I"

Torino, , Italy

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Private practice

Kętrzyn, , Poland

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Private practice

Komorów, , Poland

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Private practice

Lublin, , Poland

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Private Practice

Opole, , Poland

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Gravida Specjalistyczny Osrodek Ginekologii i Poloznictwa

Płock, , Poland

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Centrum Zdrowia mama i Ja

Wroclaw, , Poland

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Gabinet Ginekologiczny

Żory, , Poland

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Hospital do Espirito santo de Évora

Evora, , Portugal

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Hospital da Luz-Lisboa

Lisbon, , Portugal

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Spitalul Clinic de Urgenta Militar Central

Bucharest, , Romania

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OG Clinic II " Dominic Stanca "

Cluj-Napoca, , Romania

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Spitalul Clinic de Urgenta

Târgu Mureş, , Romania

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Hospital del Mar

Barcelona, , Spain

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Hospital Sant Pau

Barcelona, , Spain

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Hospital de la Zarzuela

Madrid, , Spain

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Hospital Virgen de la Macarena

Seville, , Spain

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Hospital Virgen de la Salud

Toledo, , Spain

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Bradford Royal Infirmary

Bradford, , United Kingdom

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North Cumbria University Hospitals NHS Trust

Carlisle, , United Kingdom

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Hull and East Yorshire Eye Hospital

East Yorkshire, , United Kingdom

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Epsom & St Helier University Hospitals NHS Trust

Epsom Surrey, , United Kingdom

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Royal devon and Exeter hospital

Exeter, , United Kingdom

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Royal Hampshire County Hospital

Hampshire, , United Kingdom

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University Hospitals of Leicester NHS Trust

Leicester, , United Kingdom

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Liverpool Womens hospital

Liverpool, , United Kingdom

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Barts and The London School of Medicine

London, , United Kingdom

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King's College Hospital NHS Foundation

London, , United Kingdom

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Nottingham University Hospital NHS trust

Nottingham, , United Kingdom

Site Status

Southampton University Hospital

Southampton, , United Kingdom

Site Status

Countries

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Austria France Germany Hungary Italy Poland Portugal Romania Spain United Kingdom

References

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Fernandez H, Descamps P, Koskas M, Lopes P, Brun JL, Darai E, Agostini A. Real-world data of 197 patients treated with ulipristal acetate for uterine fibroids: PREMYA study French population main outcomes. J Gynecol Obstet Hum Reprod. 2017 Sep;46(7):559-564. doi: 10.1016/j.jogoh.2017.06.006. Epub 2017 Jul 1.

Reference Type DERIVED
PMID: 28676450 (View on PubMed)

Other Identifiers

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PGL10-014

Identifier Type: -

Identifier Source: org_study_id

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