Study of Proellex in Pre-menopausal Women With Symptomatic Uterine Fibroids

NCT ID: NCT00882258

Last Updated: 2014-07-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

144 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-03-31

Study Completion Date

2007-03-31

Brief Summary

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Two (2) dose levels of Proellex or placebo will be administered once-daily for up to 91 days. Following screening and a pre-treatment endometrial biopsy, subjects will be followed monthly for the three month treatment phase.

Detailed Description

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Two (2) dose levels of Proellex or placebo will be administered once-daily for up to 91 days. Following screening and a pre-treatment endometrial biopsy, subjects will be followed monthly for the three month treatment phase. At the three-month treatment visit, subjects will be entered into an open-label extension treatment protocol, if deemed eligible. At four months after their first treatment visit, subjects not electing to enter the open-label study will be assessed at a final follow-up visit.

Conditions

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Uterine Fibroids

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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12.5 mg Proellex

Proellex 12.5 mg daily

Group Type EXPERIMENTAL

12.5 mg Proellex

Intervention Type DRUG

12.5 mg Proellex administered orally daily

25 mg Proellex daily

Proellex 25 mg

Group Type EXPERIMENTAL

25 mg Proellex

Intervention Type DRUG

25 mg Proellex administered orally daily

Placebo

Placebo daily

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Administered orally daily

Interventions

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12.5 mg Proellex

12.5 mg Proellex administered orally daily

Intervention Type DRUG

25 mg Proellex

25 mg Proellex administered orally daily

Intervention Type DRUG

Placebo

Administered orally daily

Intervention Type DRUG

Other Intervention Names

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CDB-4124 Telapristone acetate CDB-4124 Telapristone acetate Dummy

Eligibility Criteria

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Inclusion Criteria

* At least one leiomyoma must have been identifiable and measurable by abdominal/pelvic ultrasound.
* Must have had a history of one or both of the following leiomyomata-associated symptoms, excessive menstrual bleeding, or pain

Exclusion Criteria

* Post-menopausal women, as defined as one or more of the following:

1. six months or more (immediately prior to Screening visit) without a menstrual period, or
2. prior hysterectomy and/or oophorectomy
* Subjects with documented endometriosis
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Repros Therapeutics Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Andre VanAs, PhD, MD

Role: STUDY_DIRECTOR

Repros Therapeutics Inc.

Locations

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Alabama Clinical Therapeutics, LLC

Birmingham, Alabama, United States

Site Status

Women's Health Research

Phoenix, Arizona, United States

Site Status

Arizona Wellness Centre for Women

Phoenix, Arizona, United States

Site Status

Visions Clinical Research Tuscon

Tuscon, Arizona, United States

Site Status

Medical Centre for Clinical Research

San Diego, California, United States

Site Status

Women's Health Care, Inc.

San Diego, California, United States

Site Status

Downtown Women's Health Care

Denver, Colorado, United States

Site Status

Visions Clinical Research

Boynton Beach, Florida, United States

Site Status

Miami Research Associates, Women's Health Studies

Miami, Florida, United States

Site Status

Insignia Clinical Research (Tampa Bay Women's Center)

Tampa, Florida, United States

Site Status

Caring for Women

Las Vegas, Nevada, United States

Site Status

Affiliated Clinical Research, Inc.

Las Vegas, Nevada, United States

Site Status

SC Clinical Research Center

Columbia, South Carolina, United States

Site Status

Advances in Health Inc.

Houston, Texas, United States

Site Status

Obstetrical & Gynecolgical Associates, PA (OGA)

Houston, Texas, United States

Site Status

Women's Clinical Research Centre

Seattle, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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ZPU-003

Identifier Type: -

Identifier Source: org_study_id

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