Preventive Effect of Proprioceptive Stimulation on Muscle Atrophy
NCT ID: NCT01641627
Last Updated: 2015-04-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1/PHASE2
34 participants
INTERVENTIONAL
2012-03-31
2015-03-31
Brief Summary
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Data underline the importance of afferent input integrity in the maintenance of muscle characteristics and postural control, and suggest that countermeasure programs based on the stimulation of proprioceptive inputs could be efficient to prevent muscle atrophy and falls. In particular, fundamental studies performed in rodents by the investigators laboratory have demonstrated that the adverse structural and functional adaptations which occur during muscle deconditioning can be counteracted through adequate physiological stimuli such as activation of proprioceptors. Based on this scientific expertise, the investigators aim is thus to prevent muscle atrophy and its functional consequences on posture and locomotion, following a surgical intervention in humans .
The investigators will develop a device allowing stimulation of foot and ankle proprioceptors. In order to facilitate the evaluation of its efficiency, the device will be tested on a selected population confined to bed during a post-operative period (knee replacement). It efficiency will be evaluated by means of three parameters: muscle force of ankle plantar flexor, muscle volume of lower limb muscles, functional outcome (gait and balance analysis).
The technique developed in the present project could bring benefits to patients confined to bed, or in elderly. Preventing or retarding development of muscle atrophy will beneficiate to health and quality of life of these patients. In addition, this device might allow to consider therapeutic strategies for prevention of atrophy in neuromuscular pathologies.
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Detailed Description
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The investigators developped a safe vibration and pressure stimulation device for le lower limb. The investigators want to carry out a RCT in order to demonstrate the efficacy of the stimulation device, compared to a not stimulated controle group.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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vibration
proprioceptive stimulation of the lower limb using vibration and plantar pressure boots
proprioceptive stimulation
tendon vibrations and plantar stimulation with a therapeuthic orthosis, 4x30 min/day during 14 days
Interventions
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proprioceptive stimulation
tendon vibrations and plantar stimulation with a therapeuthic orthosis, 4x30 min/day during 14 days
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
80 Years
ALL
No
Sponsors
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University Hospital, Lille
OTHER
Responsible Party
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Principal Investigators
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vincent TIFFREAU, MD-PhD
Role: PRINCIPAL_INVESTIGATOR
Univerity Hospital Lille 2
Locations
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CHRU de Lille
Lille, Nord, France
Countries
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Other Identifiers
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2011-A0031-40
Identifier Type: OTHER
Identifier Source: secondary_id
2010_05
Identifier Type: -
Identifier Source: org_study_id
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